N-(2-HYDROXYETHYL)TRIFLUOROACETAMIDE
N-(trifluoroacetyl)ethanolamine
CAS: 6974-29-4
Molecular Formula: C4H6F3NO2
N-(2-HYDROXYETHYL)TRIFLUOROACETAMIDE - Names and Identifiers
N-(2-HYDROXYETHYL)TRIFLUOROACETAMIDE - Physico-chemical Properties
| Molecular Formula | C4H6F3NO2 |
| Molar Mass | 157.09 |
| Density | 1.413 g/mL at 25 °C (lit.) |
| Melting Point | 32-35 °C (lit.) |
| Boling Point | 234.7°C at 760 mmHg |
| Flash Point | 135°F |
| Vapor Presure | 0.00953mmHg at 25°C |
| BRN | 1934914 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.375 |
N-(2-HYDROXYETHYL)TRIFLUOROACETAMIDE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
N-(2-HYDROXYETHYL)TRIFLUOROACETAMIDE - Introduction
N-(trifluoroacetyl)ethanolamine, also known as N-(trifluoroacetyl)ethanolamine, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: A colorless to light yellow liquid.
-Molecular formula: C4H6F3NO2.
-Molecular weight: 151.09g/mol.
-Melting point:-41 ℃.
-Boiling point: 230 ℃.
-Solubility: Soluble in water and most organic solvents.
Use:
- N-(trifluoroacetyl)ethanolamine are mainly used as pharmaceutical intermediates for the synthesis of compounds and drugs.
-Because it contains amino and hydroxyl groups, it can also be used as a catalyst or an amino protecting reagent in the reaction.
Preparation Method:
- N-(trifluoroacetyl)ethanolamine can be prepared by the following steps:
1. Trifluoroacetyl chloride (trifluoroacetyl chloride) reacts with ethanolamine (ethanolamine) to generate trifluoroacetamido ethanol (trifluoroacetaminoethanol).
2. The trifluoroacetamidoethanol is then reacted with sodium hydroxide (sodium hydroxide) to generate N-(trifluoroacetyl)ethanolamine under alkaline conditions.
Safety Information:
- N-(trifluoroacetyl)ethanolamine is a chemical and should be handled with caution.
-Avoid contact with oxidizing agents, strong acids or strong bases during use or storage.
-Appropriate protective equipment such as chemical respirators, goggles and chemical suits should be worn.
-In case of contact with skin or eyes, rinse immediately with water for at least 15 minutes and seek medical help.
-Avoid prolonged exposure to the outdoors, avoid inhalation or ingestion.
-In storage and handling, to comply with the appropriate safety procedures and laws and regulations.
Nature:
-Appearance: A colorless to light yellow liquid.
-Molecular formula: C4H6F3NO2.
-Molecular weight: 151.09g/mol.
-Melting point:-41 ℃.
-Boiling point: 230 ℃.
-Solubility: Soluble in water and most organic solvents.
Use:
- N-(trifluoroacetyl)ethanolamine are mainly used as pharmaceutical intermediates for the synthesis of compounds and drugs.
-Because it contains amino and hydroxyl groups, it can also be used as a catalyst or an amino protecting reagent in the reaction.
Preparation Method:
- N-(trifluoroacetyl)ethanolamine can be prepared by the following steps:
1. Trifluoroacetyl chloride (trifluoroacetyl chloride) reacts with ethanolamine (ethanolamine) to generate trifluoroacetamido ethanol (trifluoroacetaminoethanol).
2. The trifluoroacetamidoethanol is then reacted with sodium hydroxide (sodium hydroxide) to generate N-(trifluoroacetyl)ethanolamine under alkaline conditions.
Safety Information:
- N-(trifluoroacetyl)ethanolamine is a chemical and should be handled with caution.
-Avoid contact with oxidizing agents, strong acids or strong bases during use or storage.
-Appropriate protective equipment such as chemical respirators, goggles and chemical suits should be worn.
-In case of contact with skin or eyes, rinse immediately with water for at least 15 minutes and seek medical help.
-Avoid prolonged exposure to the outdoors, avoid inhalation or ingestion.
-In storage and handling, to comply with the appropriate safety procedures and laws and regulations.
Last Update：2024-04-09 21:04:16
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