N-(2-Methoxyphenyl)acetamide

Name	N-(2-Methoxyphenyl)acetamide
Synonyms	o-Acetanisidide 2-acetanisidide Anisidide, o-acet- O-acetamidoanisole 2'-methoxy-acetanilid 6-chloro-9-octylpurine Acetanilide, 2'-methoxy- N-(2-METHOXYPHENYL)ACETAMIDE 2-Acetylaminomethylphenoxide N-(2-Methoxyphenyl)acetamide Acetamide, N-(2-methoxyphenyl)-
CAS	93-26-5
EINECS	202-233-5
InChI	InChI=1/C9H11NO2/c1-7(11)10-8-5-3-4-6-9(8)12-2/h3-6H,1-2H3,(H,10,11)
InChIKey	FGOFNVXHDGQVBG-UHFFFAOYSA-N

Molecular Formula	C9H11NO2
Molar Mass	165.19
Density	1.1603 (rough estimate)
Melting Point	70-74 °C (lit.)
Boling Point	303-305 °C (lit.)
Flash Point	138.091°C
Vapor Presure	0.001mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
pKa	14.50±0.70(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5839 (estimate)
MDL	MFCD00026117
Physical and Chemical Properties	White needle crystal. Melting point 87~88 ℃, boiling point 303~305 ℃. The solubility in water, acetic acid, ether and ethanol is above 10%.

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	AE8280000
Toxicity	LD50 orl-mus: 940 mg/kg TXAPA9 19,20,71

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Use	as raw materials for organic synthesis, used in the manufacture of pesticides, pharmaceuticals, etc. for the production of red-based B
production method	is obtained by reacting anthranilic ether with acetic anhydride. A metered amount of O-aminoanisole was put into the reaction kettle, and glacial acetic acid was added with stirring. Acetic anhydride was added dropwise at 10 to 12 ° C., the addition was completed for about 2 hours, and the mixture was allowed to stand for 2 hours to obtain an intermediate, O-acetamidoanisole, for industrial use. The compounding ratio was anthranilic ether: glacial acetic acid: Acetic anhydride = 1:0.9:1 (weight ratio). It is also possible to mix anthranilic ether with acetic anhydride, reflux in a sand bath for 2H, let it cool to obtain needle-like crystals, filter, wash off the acidity with water, and recrystallize with water to obtain a finished product.
category	toxic substances
toxicity grade	poisoning
Acute toxicity	oral-mouse LD50:940 mg/kg
flammability hazard characteristics	flammable; Toxic nitrogen oxide smoke released by thermal decomposition
storage and transportation characteristics	warehouse ventilation and low temperature drying
extinguishing agent	dry powder, foam, sand and water