N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide - Names and Identifiers
N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide - Physico-chemical Properties
N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide - Upstream Downstream Industry
N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide - Introduction
N-(2-broMo-3-Methoxyphenyl) glutarimide (N-(2-broMo-3-Methoxyphenyl)pivalamide) is an organic compound. Its chemical formula is C13H16BrNO2 and its molecular weight is 303.18g/mol. It is a solid with a common appearance of white to off-white crystals. The following is a detailed description of the properties, uses, preparation and safety information of N-(2-bromo-3-methoxyphenyl) glutarimide:
Nature:
-Appearance: White to off-white crystal
-Melting Point: 75-78 ℃
-Boiling point: 373.7 ℃
-Density: 1.449g/cm³
-Solubility: Soluble in ethanol, ether, dichloromethane and other common organic solvents
Use:
N-(2-bromo-3-methoxyphenyl) glutarimide can be used as an intermediate in organic synthesis. It has potential application value in the field of medicine, and may be used in the synthesis of drugs or pharmaceutical intermediates. In addition, it may be used as a catalyst, a reducing agent or a protecting group in other organic synthesis reactions.
Method:
The preparation of N-(2-bromo-3-methoxyphenyl) glutarimide is usually carried out by the following steps:
1. Dissolve 2-bromo-3-methoxyaniline in acetonitrile;
2. Adding excess tert-butyl sodium bromide for reaction;
3. Heat the reaction mixture and maintain the reaction temperature at 90-100°C;
4. After the reaction, the product is obtained by filtration;
5. The product was purified by recrystallization.
Safety Information:
The safety information of N-(2-bromo-3-methoxyphenyl) glutarimide needs to be further evaluated, so appropriate laboratory safety measures should be taken when using or operating. Exposure to direct sunlight or high temperatures should be avoided. At the same time, it is necessary to wear appropriate personal protective equipment, such as laboratory coats, goggles and gloves. In case of accidental splashing into eyes, skin or inhalation, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:11:58