N-(2-methylphenyl)-2-(propylamino)propionamide
Prilocaine
CAS: 721-50-6
Molecular Formula: C13H20N2O
N-(2-methylphenyl)-2-(propylamino)propionamide - Names and Identifiers
| Name | Prilocaine |
| Synonyms | astra1512 Prilocaine Prilocaine (200 mg) Prilocaine HCl (base) 2-(propylamino)propion-o-toluidide 2-(PropylaMino)-N-(o-tolyl)propanaMide N-(2-methylphenyl)-2-(propylamino)propionamide N-(2-Methylphenyl)-2-(propylamino)propa-namide o-Propionotoluidide, 2-(propylamino)- (6CI, 8CI) Propanamide, N-(2-methylphenyl)-2-(propylamino)- (9CI) Prilocaine N-(2-Methylphenyl)-2-propylamino-propanamide |
| CAS | 721-50-6 |
| EINECS | 211-957-0 |
| InChI | InChI=1/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) |
| InChIKey | MVFGUOIZUNYYSO-UHFFFAOYSA-N |
N-(2-methylphenyl)-2-(propylamino)propionamide - Physico-chemical Properties
| Molecular Formula | C13H20N2O |
| Molar Mass | 220.31 |
| Density | 1.0117 (rough estimate) |
| Melting Point | 37-38° |
| Boling Point | bp0.1 159-162° |
| Water Solubility | 6.169g/L(25 ºC) |
| Solubility | Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent). |
| Appearance | neat |
| pKa | pKa 7.32 or 7.89 (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | nD20 1.5298 |
| Physical and Chemical Properties | Properties: |
| Use | Local anesthetic. The drug efficacy is better than procaine, the intensity and speed of local anesthesia is similar to lidocaine, but the action time is longer, the toxicity is smaller, the metabolism is faster, and the accumulation is smaller. Suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia. |
| In vitro study | Prilocaine is more potent in inhibiting the Na,K-ATPase of plasma membranes of LM cells (transformed fibroblasts) at 37 ℃ (43.8 mM) than at 25 ℃ (28.2 mM). |
N-(2-methylphenyl)-2-(propylamino)propionamide - Risk and Safety
| HS Code | 2924296000 |
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