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N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-py

CAS: 1375465-09-0

Molecular Formula: C26H27F4N7O2

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N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide - Names and Identifiers

Name N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-py
Synonyms CNX2006
CS-1000
CNX-2006
CNX 2006
N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-py
N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
N-[3-({2-[(4-{[1-(2-Fluoroethyl)-3-azetidinyl]amino}-2-methoxyphe nyl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)phenyl]acrylam ide
N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]aMino]-2-Methoxyphenyl]aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]phenyl]-2-propenaMide
2-Propenamide, N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-
CNX 2006 N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide
CAS 1375465-09-0

N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide - Physico-chemical Properties

Molecular FormulaC26H27F4N7O2
Molar Mass545.53
Density1.396±0.06 g/cm3(Predicted)
pKa13.23±0.70(Predicted)
Storage Condition2-8℃
UseCNX-2006 is an irreversible EGFR mutant inhibitor. The IC50 value for EGFRT790M is less than 20 nM.
In vitro studyCNX-2006 is a new type of irreversible EGFR tyrosine kinase inhibitor, especially inhibiting the activation of EGFR mutation and T790M mutation, and the inhibition of wild type EGFR is very weak. In an in vitro model of acquired resistance, continuous CNX-2006 treatment of drug-sensitive EGFR mutant cells caused resistance slower than erlotinib. A CNX-2006 dose increase caused different effects in different strains, but was not selective for T790M-mediated resistance. CNX-2006 drug resistant cells showed increased expression of EMT markers and mmp9.
In vivo studyCNX-2006 was effective in the H1975 (EGFR L858R/T790M) xenograft model.

N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.833 ml9.165 ml18.331 ml
5 mM0.367 ml1.833 ml3.666 ml
10 mM0.183 ml0.917 ml1.833 ml
5 mM0.037 ml0.183 ml0.367 ml
Last Update：2024-01-02 23:10:35
N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-py Visit Supplier Webpage Request for quotation
CAS: 1375465-09-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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N-(3-((2-((4-((1-(2-Fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
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