N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide - Names and Identifiers
Name | N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
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Synonyms | Neratinib Impurity 18 Neratinib Intermediate4 N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl) 3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline N-(3-Cyan-7-ethoxy-4-hydroxychinolin-6-yl)acetamid 3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinoline 3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinolone N-(3-cyano-7-ethoxy-4-oxo-1H-quinolin-6-yl)acetamide N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetaMide N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
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CAS | 848133-75-5
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InChI | InChI=1/C14H13N3O3/c1-3-20-13-5-11-10(4-12(13)17-8(2)18)14(19)9(6-15)7-16-11/h4-5,7H,3H2,1-2H3,(H,16,19)(H,17,18) |
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide - Physico-chemical Properties
Molecular Formula | C14H13N3O3
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Molar Mass | 271.27 |
Density | 1.35±0.1 g/cm3(Predicted) |
Melting Point | >250℃ |
Boling Point | 552.1±50.0 °C(Predicted) |
Flash Point | 244.962°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 0.84±0.50(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.61 |
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide - Introduction
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is an organic compound with the chemical formula C15H15N3O7.
Nature:
-Appearance: N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is a white to pale yellow solid.
-Solubility: It is soluble in ethanol, dimethyl sulfoxide and dichloromethane, but has low solubility in water.
Use:
-Chemical reagent: N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide can be used as a chemical reagent for organic synthesis reactions.
-Drug intermediate: It can also be used as a drug intermediate for the synthesis of biologically active compounds.
Preparation Method:
The synthesis of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide is complex and involves multiple steps. A common synthesis method is to carry out the synthesis reaction starting from quinoline as the starting material, and then gradually introduce cyano group, hydroxyl group, acetylamino group and ethoxy group through a multi-step reaction.
Safety Information:
Regarding the safety information of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide, the toxicity and danger of this compound have not been reported in detail. In general, when performing experiments, you should wear appropriate personal protective equipment, such as laboratory gloves and protective glasses, to avoid direct contact with skin and eyes. At the same time, the relevant safety operation procedures should be observed during operation and storage to ensure personal safety and the safety of the experimental environment.
Last Update:2024-04-09 21:54:55