N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
ML-323
CAS: 1572414-83-5
Molecular Formula: C23H24N6
N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine - Names and Identifiers
N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine - Physico-chemical Properties
| Molecular Formula | C23H24N6 |
| Molar Mass | 384.48 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Boling Point | 515.4±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 49 mg/mL |
| Appearance | solid |
| Color | White |
| pKa | 5.37±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | ML323 inhibited PCNA and FANCD2 Deubiquitination by inhibiting USP1-UAF1 activity in H596 cells. In addition, ML323 enhanced cisplatin toxicity in H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA). |
N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine - Risk and Safety
| HS Code | 29299090 |
N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.601 ml | 13.005 ml | 26.009 ml |
| 5 mM | 0.52 ml | 2.601 ml | 5.202 ml |
| 10 mM | 0.26 ml | 1.3 ml | 2.601 ml |
| 5 mM | 0.052 ml | 0.26 ml | 0.52 ml |
Last Update：2024-01-02 23:10:35
N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine - Introduction
ML-323 is a chemical, also known as ML323, which belongs to a class of compounds called benzoquinazolinone derivatives. The following is a description of the nature, use, preparation and safety information of the ML-323:
Nature:
- ML-323 is a white solid, soluble in DMSO (dimethyl sulfoxide) and methanol.
-Its chemical formula is C21H17BrN4O2, and its molecular weight is 439.29g/mol.
Use:
- ML-323 is a selective BRD4 (chromatin structure readable domain 4) inhibitor, which can inhibit the interaction between BRD4 and the reversible DNA binding protein (Bromodomain in BRD).
-It is very useful for studying the treatment of BRD4 and related diseases such as cancer, inflammation and viral infection.
Preparation Method:
-There are many ways to synthesize ML-323. One of the common methods is to obtain benzoquinazolinone as raw material through corresponding chemical reactions.
Safety Information:
-Information on the safety and toxicity of ML-323 is limited and requires caution before use.
-Because it is a laboratory research compound, users should follow relevant safety procedures during operation and wear appropriate personal protective equipment, such as laboratory gloves, safety glasses, etc.
-Keep away from open flames and heat sources during operation, and avoid high temperature and humidity during storage. If ingestion or contact with eyes or skin, wash immediately and seek medical help.
-When using ML-323 in a laboratory environment, special attention should be paid to storage and disposal methods, and relevant regulations and laboratory safety standards should be followed.
Nature:
- ML-323 is a white solid, soluble in DMSO (dimethyl sulfoxide) and methanol.
-Its chemical formula is C21H17BrN4O2, and its molecular weight is 439.29g/mol.
Use:
- ML-323 is a selective BRD4 (chromatin structure readable domain 4) inhibitor, which can inhibit the interaction between BRD4 and the reversible DNA binding protein (Bromodomain in BRD).
-It is very useful for studying the treatment of BRD4 and related diseases such as cancer, inflammation and viral infection.
Preparation Method:
-There are many ways to synthesize ML-323. One of the common methods is to obtain benzoquinazolinone as raw material through corresponding chemical reactions.
Safety Information:
-Information on the safety and toxicity of ML-323 is limited and requires caution before use.
-Because it is a laboratory research compound, users should follow relevant safety procedures during operation and wear appropriate personal protective equipment, such as laboratory gloves, safety glasses, etc.
-Keep away from open flames and heat sources during operation, and avoid high temperature and humidity during storage. If ingestion or contact with eyes or skin, wash immediately and seek medical help.
-When using ML-323 in a laboratory environment, special attention should be paid to storage and disposal methods, and relevant regulations and laboratory safety standards should be followed.
Last Update：2024-04-10 22:29:15
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CAS: 1572414-83-5
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Product Name: ML-323 Visit Supplier Webpage Request for quotation
CAS: 1572414-83-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1572414-83-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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