N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
UNC2881
CAS: 1493764-08-1
Molecular Formula: C25H33N7O2
N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide - Names and Identifiers
N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide - Physico-chemical Properties
| Molecular Formula | C25H33N7O2 |
| Molar Mass | 463.58 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 12.70±0.46(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | UNC2881 inhibits Mer kinase activity at an IC50 of 22 nM in 697 B- ALL cells and inhibits collagen-stimulated platelet aggregation. UNC2881 inhibits Mer kinase activity at an IC50 of 22 nM in 697 B- ALL cells and inhibits collagen-stimulated platelet aggregation. |
| In vivo study | In mice, UNC2881 had high total clearance (94.5/min/kg) and oral bioavailability of 14%. In Mice, UNC2881 had high total clearance (94.5/min/kg) and oral bioavailability of 14%. |
N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.157 ml | 10.786 ml | 21.571 ml |
| 5 mM | 0.431 ml | 2.157 ml | 4.314 ml |
| 10 mM | 0.216 ml | 1.079 ml | 2.157 ml |
| 5 mM | 0.043 ml | 0.216 ml | 0.431 ml |
Last Update：2024-01-02 23:10:35
N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide - Introduction
UNC2881 is an organic compound also known as UNC-2881 or UNC 2881. It has the following properties:
1. Appearance: UNC2881 is a white solid, insoluble in water at room temperature.
2. Molecular formula: C22H26N4O2
3. Molecular weight: 382.47g/mol
4. Melting point: The melting point range of UNC2881 is 170-176 ℃.
The main use of UNC2881 is as a reagent in the field of pharmaceutical research. It is a dual inhibitor of PARP (polymerase -1) and TNKS(TANK-Binding Kinase), used to study the function of these enzymes and their relationship with cell proliferation, the relevance of processes such as DNA repair and apoptosis.
The preparation method of UNC2881 can be realized by chemical synthesis, but the specific synthetic route needs further reference to relevant scientific literature or professional research reports, because this information may be updated.
1. Appearance: UNC2881 is a white solid, insoluble in water at room temperature.
2. Molecular formula: C22H26N4O2
3. Molecular weight: 382.47g/mol
4. Melting point: The melting point range of UNC2881 is 170-176 ℃.
The main use of UNC2881 is as a reagent in the field of pharmaceutical research. It is a dual inhibitor of PARP (polymerase -1) and TNKS(TANK-Binding Kinase), used to study the function of these enzymes and their relationship with cell proliferation, the relevance of processes such as DNA repair and apoptosis.
The preparation method of UNC2881 can be realized by chemical synthesis, but the specific synthetic route needs further reference to relevant scientific literature or professional research reports, because this information may be updated.
Last Update：2024-04-09 19:05:02
Supplier List
Product Name: UNC2881 Visit Supplier Webpage Request for quotation
CAS: 1493764-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1493764-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: UNC2881 Visit Supplier Webpage Request for quotation
CAS: 1493764-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1493764-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History