N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide
N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide
CAS: 1609402-14-3
Molecular Formula: C23H22N4O3S2
N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide - Names and Identifiers
N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide - Physico-chemical Properties
| Molecular Formula | C23H22N4O3S2 |
| Molar Mass | 466.58 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| Use | HA15 is a highly effective and specific inhibitor of endoplasmic reticulum chaperone protein BiP/GRP78/HSPA5, which can inhibit the ATPase activity of BiP and has anti-tumor activity. |
| In vitro study | HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; In melanoma cells, it overcomes resistance to BRAF inhibitors. |
| In vivo study | In a xenograft mouse model (harboring melanoma cells that are sensitive or resistant to BRAF inhibitors),HA15 is able to induce endoplasmic reticulum stress leading to cancer cell death. |
N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.143 ml | 10.716 ml | 21.433 ml |
| 5 mM | 0.429 ml | 2.143 ml | 4.287 ml |
| 10 mM | 0.214 ml | 1.072 ml | 2.143 ml |
| 5 mM | 0.043 ml | 0.214 ml | 0.429 ml |
Last Update：2024-01-02 23:10:35
N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide - Reference Information
| biological activity | HA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), which can also be called BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). It has anti-tumor activity in the detected melanoma cells, including cells isolated from patients and cells resistant to BRAF inhibitors. |
| target | TargetValue BiP/GRP78/HSPA5 () |
| Target | Value |
| in vitro study | HA15 induces endoplasmic reticulum stress in in vitro cells, leading to cancer cell death; in melanoma cells, overcome its resistance to BRAF inhibitors. |
| In vivo studies | In a xenograft mouse model (carrying melanoma cells that are sensitive or resistant to BRAF inhibitors),HA15 can induce endoplasmic reticulum stress, which leads to cancer cell death. |
Last Update：2024-04-09 21:54:55
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Product Name: N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide Visit Supplier Webpage Request for quotationCAS: 1609402-14-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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