N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide
CL-387785
CAS: 194423-06-8
Molecular Formula: C18H13BrN4O
N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide - Names and Identifiers
N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide - Physico-chemical Properties
| Molecular Formula | C18H13BrN4O |
| Molar Mass | 381.23 |
| Density | 1.577±0.06 g/cm3(Predicted) |
| Melting Point | 276 °C |
| Solubility | DMSO: 13.67 mg/mL |
| Appearance | Off-white to yellow solid. |
| pKa | 9.84±0.43(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | CL-387785 blocks EGF-mediated receptor autophosphorylation in cells with an IC50 value of 5 nM. Of the cell lines that overexpressed EGF-R or c-erbB-2, CL-387785 inhibited cell proliferation predominantly as a cytostatic with an IC50 value of 31 nM. |
| In vivo study | In nude mice overexpressing EGF-R, CL-387785(80 mg/kg/day, P. O.) effectively inhibited tumor growth. In the autosomal recessive polycystic kidney disease mouse model (ARPKD), Balb/EKI-785/bpk (BPK) mice were treated with c-bpk (90 mg/kg, I. P.), can significantly reduce the collection of tubular cystic lesions, improve renal function, reduce bile duct epithelial cell abnormalities, prolong survival. The EKI-785 dose as low as 25 mg/kg was able to reduce the xenograft tumor growth induced by HCA-7, and the dose of 100 mg/kg completely inhibited tumor growth. CL-387785 at 50 mg/kg was effective in inhibiting HCT-116 of the induced xenograft growth. |
N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.623 ml | 13.116 ml | 26.231 ml |
| 5 mM | 0.525 ml | 2.623 ml | 5.246 ml |
| 10 mM | 0.262 ml | 1.312 ml | 2.623 ml |
| 5 mM | 0.052 ml | 0.262 ml | 0.525 ml |
Last Update：2024-01-02 23:10:35
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Product Name: CL-387785 Visit Supplier Webpage Request for quotationCAS: 194423-06-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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