N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE

Name	NAPHTHOL AS-E PHOSPHATE
Synonyms	KG501 kg-501 KG 501 NASEP KG-501 NAPHTHOL AS-E PHOSPHATE NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
CAS	18228-17-6
EINECS	242-106-1

Molecular Formula	C17H13ClNO5P
Molar Mass	377.72
Density	1.567±0.06 g/cm3(Predicted)
BRN	6664478
pKa	1.04±0.30(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
In vitro study	KG-501 inhibits (or partially inhibits) the induction of cAMP-related genes by preventing CREB:CBP interactions. KG-501 inhibited neurite outgrowth, synaptogenesis and decreased MAP2 neurons.
In vivo study	KG-501 inhibited the expression of CREB, CCL2 and ERK phosphorylation while significantly reducing cAMP levels. CREB may help protect nerves against neuroinflammation through the cAMP/ERKadjustment pathway. KG-501 significantly promoted neurological function in the azoxymethane (AOM)-treated mouse model, reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

WGK Germany	3
FLUKA BRAND F CODES	8-10-21

Last Update：2024-01-02 23:10:35

Biological activity	KG-501 (2-naphthol-AS-E-phosphate) is a CREB inhibitor, which destroys the transcription of CREB (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It can also destroy the binding of phosphorylated CREB(Ser-133) to KIX, Ki is about 90 μM.
target	TargetValue CREB ()
Target	Value
In vitro study	KG-501 inhibits (or partially inhibits) the induction of cAMP-related genes by preventing the CREB:CBP interaction. KG-501 inhibits neurite proliferation, synaptogenesis and reduces MAP2 nerve cells.
in vivo study	KG-501 inhibited the expression of CREB, CCL2 and ERK phosphorylation, and significantly reduced the level of cAMP. CREB may help fight neuroinflammation through cAMP/ERKadjustment pathway, thus protecting nerves. KG-501 significantly promoted the neurological function of azomethane oxide (AOM)-treated mouse models and reduced the level of ERK phosphorylation and cAMP concentration in the cortex.

Last Update：2024-04-09 20:52:54

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CAS: 18228-17-6
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409

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