N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride
PJ34 HCl
CAS: 344458-15-7
Molecular Formula: C17H17N3O2HCl
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride - Names and Identifiers
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride - Physico-chemical Properties
| Molecular Formula | C17H17N3O2HCl |
| Molar Mass | 331.8 |
| Solubility | H2O: soluble22mg/mL |
| Appearance | White solid |
| Color | white to yellow |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Sensitive | Light Sensitive & Hygroscopic |
| Use | PJ34 HCl is a hydrochloride form of PJ34 and is a PARP inhibitor with EC50 of 20 nM, which is equally effective on PARP1/2. |
| In vitro study | PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M. |
| In vivo study | To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice. |
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29339900 |
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.014 ml | 15.069 ml | 30.139 ml |
| 5 mM | 0.603 ml | 3.014 ml | 6.028 ml |
| 10 mM | 0.301 ml | 1.507 ml | 3.014 ml |
| 5 mM | 0.06 ml | 0.301 ml | 0.603 ml |
Last Update：2024-01-02 23:10:35
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride - Reference Information
| biological activity | PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 values of 110 nM and 86 nM, respectively. |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: PJ34 HCl Visit Supplier Webpage Request for quotationCAS: 344458-15-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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