N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine - Names and Identifiers
N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine - Physico-chemical Properties
Molecular Formula | C23H23FN4S
|
Molar Mass | 406.52 |
Density | 1.24±0.1 g/cm3(Predicted) |
Boling Point | 574.9±60.0 °C(Predicted) |
pKa | 5.16±0.61(Predicted) |
Storage Condition | Room Temprature |
In vitro study | NGP555 potently lowers Aβ 42 in cell cultures (9 nM) while increasing shorter forms of Aβ. |
In vivo study | NGP 555 has good brain permeability/absorption, distribution, metabolism and excretion (ADME) properties. It effectively crosses the blood-brain barrier with a brain-to-plasma ratio of 0.93 in Tg2576 mice and reduces Aβ42 levels in brain and plasma in rodents. Chronic administration of NGP 555 to Tg2576 mice resulted in a significant reduction in amyloid plaques. |
N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine - Introduction
The NGP 555 is a chemical called Gallium Phosphide (Gallium Phosphide Nitride). The following is an introduction to the nature, use, method and safety information of NGP 555:
Nature:
NGP 555 is a semiconductor material with a solid crystal with a light gray color. Its crystal structure is similar to that of zinc corundum. 555 of its high melting point, hardness and conductivity, NGP is widely used in electronic devices.
Use:
NGP 555 are mainly used in the manufacture of optoelectronic devices and electronic devices. Due to its semiconductor properties, it has a wide range of applications in the fields of light-emitting diodes (LEDs), semiconductor laser diodes (LEDs), solar cells, photoconductivity, microwave devices, etc.
Preparation Method:
NGP 555 are mainly manufactured by chemical vapor deposition (CVD) and molecular beam epitaxy (MBE). The CVD method uses gaseous precursors to react at high temperatures to produce NGP 555 crystals. The MBE law is to deposit the raw material on the substrate by molecular beam evaporation to form the NGP 555 film.
Safety Information:
when handling NGP 555, you need to pay attention to the following security matters:
1. NGP 555 may release toxic gases or aerosols when heated. It should be operated in a well-ventilated place and wear appropriate protective equipment.
2. When handling NGP 555 powder or film, avoid dust to prevent inhalation or contact with skin.
3. If you have inhaled NGP 555 or come into contact with the skin, rinse immediately with plenty of water and seek medical attention.
4. NGP 555 may have a negative impact on the environment and should be handled and disposed of in accordance with local environmental regulations.
it should be noted that the information of the NGP 555 described above may be limited, and the detailed nature, use, method and safety information of the NGP 555, it is recommended to consult more specialized information or experts in relevant fields for further consultation.
Last Update:2024-04-09 21:04:16