N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine
Clitocine
CAS: 105798-74-1
Molecular Formula: C9H13N5O6
N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine - Names and Identifiers
N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine - Physico-chemical Properties
| Molecular Formula | C9H13N5O6 |
| Molar Mass | 287.231 |
| Appearance | Solid |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough. Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis. |
N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine - Reference Information
| biological activity | Clitocine is an adenosine nucleoside analog derived from mushrooms and is an effective reading through. Clitocine, an inhibitor of nonsense mutations, induces p53 protein production in cells carrying the p53 nonsense mutant allele. Clitocine can induce apoptosis of multidrug-resistant tumor cells by targeting Mcl-1. Has anti-cancer activity. |
| Animal Model: | nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) |
| Dosage: | 0.3, 3 mg/kg (or 20 mg/kg once per week) |
| Administration: | S.c.; five times per week |
| Result: | CAOV-33 p53-UAA136 tumor growth was inhibited. |
Last Update：2024-04-10 22:29:15
