N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE
(S)-N-FMOC-2-Bromophenylalanine
CAS: 220497-47-2
Molecular Formula: C24H20BrNO4
N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE - Names and Identifiers
| Name | (S)-N-FMOC-2-Bromophenylalanine |
| Synonyms | Fmoc-L-2-Br-Phe Fmoc-Phe(2-Br)-OH RARECHEM BK PT 0039 FMOC-L-2-BROMOPHENYLALANINE Fmoc-L-2-Bromophenylalanine Fmoc-2-Bromo-L-phenylalanine (S)-N-FMOC-2-Bromophenylalanine (S)-N-FMOC-2-BROMOPHENYLALANINE N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMO-L-PHENYLALANINE 2-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine (2S)-3-(2-bromophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (S)-3-(2-BROMO-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID |
| CAS | 220497-47-2 |
| InChI | InChI=1/C24H20BrNO4/c25-21-12-6-1-7-15(21)13-22(23(27)28)26-24(29)30-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,26,29)(H,27,28)/p-1/t22-/m0/s1 |
N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE - Physico-chemical Properties
| Molecular Formula | C24H20BrNO4 |
| Molar Mass | 466.32 |
| Density | 1.4220 (rough estimate) |
| Melting Point | 167.8 °C |
| Boling Point | 657.1±55.0 °C(Predicted) |
| Flash Point | 351.2°C |
| Vapor Presure | 3.66E-18mmHg at 25°C |
| Appearance | Powder |
| Color | Off-white |
| pKa | 3.72±0.11(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD01311743 |
N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29223900 |
| Hazard Class | IRRITANT |
N-(9-FLUORENYLMETHOXYCARBONYL)-2-BROMOPHENYL-L-ALANINE - Introduction
(S)-N-FMOC-2-Bromophenylalanine is an amino acid derivative whose chemical structure contains structural units of 2-bromobenzeneacetic acid and the amino acid phenylalanine. Its main properties and uses are as follows:
Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C19H17BrNO4
-Molecular weight: 398.25g/mol
-Melting point: 76-80 ° C
-Solubility: Can be dissolved in organic solvents such as dimethyl sulfoxide (DMSO) or dichloromethane
Use:
(S)-N-FMOC-2-Bromophenylalanine is a commonly used chemical synthesis reagent, mainly used in peptide synthesis and protein engineering. It is usually used as a protecting group for amino acids to protect the α-amino group and side chain functional groups of amino acids from unwanted reactions before subsequent synthesis reactions. In addition,(S)-N-FMOC-2-Bromophenylalanine can also be used to synthesize peptide fragments having a particular activity or structure.
Method:
The preparation of (S)-N-FMOC-2-Bromophenylalanine is generally obtained by reacting 2-bromophenylacetic acid with phenylalanine under suitable reaction conditions. The reaction is usually carried out under basic conditions, such as sodium bicarbonate solution, at room temperature for several hours, after which the pure product is obtained by crystallization.
Safety Information:
(S)-N-FMOC-2-Bromophenylalanine as a chemical reagent, appropriate safety measures need to be taken during operation. Appropriate personal protective equipment, such as lab gloves and goggles, should be worn to prevent contact with skin or eyes. Avoid contact with oxidants and strong acids during use and storage to avoid chemical reactions and potential hazards. It is necessary to follow the relevant safety procedures of the laboratory.
Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C19H17BrNO4
-Molecular weight: 398.25g/mol
-Melting point: 76-80 ° C
-Solubility: Can be dissolved in organic solvents such as dimethyl sulfoxide (DMSO) or dichloromethane
Use:
(S)-N-FMOC-2-Bromophenylalanine is a commonly used chemical synthesis reagent, mainly used in peptide synthesis and protein engineering. It is usually used as a protecting group for amino acids to protect the α-amino group and side chain functional groups of amino acids from unwanted reactions before subsequent synthesis reactions. In addition,(S)-N-FMOC-2-Bromophenylalanine can also be used to synthesize peptide fragments having a particular activity or structure.
Method:
The preparation of (S)-N-FMOC-2-Bromophenylalanine is generally obtained by reacting 2-bromophenylacetic acid with phenylalanine under suitable reaction conditions. The reaction is usually carried out under basic conditions, such as sodium bicarbonate solution, at room temperature for several hours, after which the pure product is obtained by crystallization.
Safety Information:
(S)-N-FMOC-2-Bromophenylalanine as a chemical reagent, appropriate safety measures need to be taken during operation. Appropriate personal protective equipment, such as lab gloves and goggles, should be worn to prevent contact with skin or eyes. Avoid contact with oxidants and strong acids during use and storage to avoid chemical reactions and potential hazards. It is necessary to follow the relevant safety procedures of the laboratory.
Last Update：2024-04-10 22:29:15
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