N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL
N-fmoc-L-prolinol
CAS: 148625-77-8
Molecular Formula: C20H21NO3
N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL - Names and Identifiers
| Name | N-fmoc-L-prolinol |
| Synonyms | Fmoc-Pro-Ol FMOC-L-PRO-OL FMOC-L-PROLINOL N-fmoc-L-prolinol N-FMOC-L-PROLINOL N-ALPHA-FMOC-L-PROLINOL (S)-1-FMOC-2-PYRROLIDINEMETHANOL (S)-N-FMOC-2-PYRROLIDINEMETHANOL N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINOL 9H-fluoren-9-ylmethyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate |
| CAS | 148625-77-8 |
| InChI | InChI=1/C20H21NO3/c22-12-14-6-5-11-21(14)20(23)24-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19,22H,5-6,11-13H2/t14-/m0/s1 |
N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL - Physico-chemical Properties
| Molecular Formula | C20H21NO3 |
| Molar Mass | 323.39 |
| Density | 1.242±0.06 g/cm3(Predicted) |
| Melting Point | 90℃ |
| Boling Point | 504.6±23.0 °C(Predicted) |
| Flash Point | 259°C |
| Vapor Presure | 5.26E-11mmHg at 25°C |
| BRN | 8789847 |
| pKa | 14.77±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.616 |
N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL - Introduction
N-fmoc-L-prolinol is an organic compound with the following properties:
1. Appearance: white or white solid.
2. Solubility: soluble in some organic solvents, such as dichloromethane, chloroform and dimethyl sulfoxide.
3. Melting Point: about 172-174 ° C.
4. Molecular formula: C25H23NO.
5. Molecular weight: 361.46g/mol.
6. Storage conditions: should be stored in a dry, cool place.
One of the main uses of N-fmoc-L-prolinol is protecting groups in peptide synthesis. It can react with amino acids or peptides to form N-Fmoc-L amino acids for the synthesis of peptide chains. The protecting group of prolinol can protect the amino group of the amino acid during the synthesis to prevent its reaction. After synthesis of the peptide chain, the protecting group can be removed by a deprotection reaction under acidic conditions.
The production method of the N-fmoc-L-prolinol is generally obtained by a method of synthesizing an organic compound. A common method is to react L-prolinol with N-dimethylaminomethylpyrrolidone in the presence of N-methylpyrrolidone, formation of N-prolinol prolyl (N-fmoc-L-prolinol), followed by removal of the protecting group by treatment with acid or base gives N-fmoc-L-prolinol.
Regarding the safety information of N-fmoc-L-prolinol, it belongs to a kind of chemical, and the following matters need to be paid attention:
1. When preparing and using the N-fmoc-L-prolinol, wear appropriate protective gloves and glasses to avoid direct contact with skin and eyes.
2. In the operation should be ensured in a well-ventilated laboratory environment.
3. It can cause eye and skin irritation, so do not touch it on the eyes and skin, and avoid inhalation or intake.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and consult a doctor.
5. Storage to avoid contact with strong acid, strong alkali and oxidizing agent.
6. In the use and handling process, to follow the safe operation procedures and individual protective measures.
1. Appearance: white or white solid.
2. Solubility: soluble in some organic solvents, such as dichloromethane, chloroform and dimethyl sulfoxide.
3. Melting Point: about 172-174 ° C.
4. Molecular formula: C25H23NO.
5. Molecular weight: 361.46g/mol.
6. Storage conditions: should be stored in a dry, cool place.
One of the main uses of N-fmoc-L-prolinol is protecting groups in peptide synthesis. It can react with amino acids or peptides to form N-Fmoc-L amino acids for the synthesis of peptide chains. The protecting group of prolinol can protect the amino group of the amino acid during the synthesis to prevent its reaction. After synthesis of the peptide chain, the protecting group can be removed by a deprotection reaction under acidic conditions.
The production method of the N-fmoc-L-prolinol is generally obtained by a method of synthesizing an organic compound. A common method is to react L-prolinol with N-dimethylaminomethylpyrrolidone in the presence of N-methylpyrrolidone, formation of N-prolinol prolyl (N-fmoc-L-prolinol), followed by removal of the protecting group by treatment with acid or base gives N-fmoc-L-prolinol.
Regarding the safety information of N-fmoc-L-prolinol, it belongs to a kind of chemical, and the following matters need to be paid attention:
1. When preparing and using the N-fmoc-L-prolinol, wear appropriate protective gloves and glasses to avoid direct contact with skin and eyes.
2. In the operation should be ensured in a well-ventilated laboratory environment.
3. It can cause eye and skin irritation, so do not touch it on the eyes and skin, and avoid inhalation or intake.
4. In case of contact with skin or eyes, rinse immediately with plenty of water and consult a doctor.
5. Storage to avoid contact with strong acid, strong alkali and oxidizing agent.
6. In the use and handling process, to follow the safe operation procedures and individual protective measures.
Last Update：2024-04-10 22:29:15
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