N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE
9-Fluorenylmethyl N-hydroxycarbamate
CAS: 190656-01-0
Molecular Formula: C15H13NO3
N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE - Names and Identifiers
| Name | 9-Fluorenylmethyl N-hydroxycarbamate |
| Synonyms | FMOC-NH-OH Fmoc-Nh-Oh FMOC-HYDROXYLAMINE Fmoc-Hydroxylamine N-FMOC-HYDROXYLAMINE N-Fmoc-Hydroxylamine 9-Fluorenylmethyl N-hydroxycarbamate 9-FLUORENYLMETHYL N-HYDROXYCARBAMATE 9H-Fluoren-9-Ylmethyl Hydroxycarbamate N-(9-FLUORENYLMETHOXYCARBONYL)HYDROXYLAMINE N-(9-Fluorenylmethoxycarbonyl)Hydroxylamine N-(9-Fluorenylmetyloxycarbonyl)-Hydroxylamine N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE N-(9-Fluorenylmethoxycarbonyl)Hydroxylamine, N-Fmoc-Hydroxylamine |
| CAS | 190656-01-0 |
| InChI | InChI=1/C15H13NO3/c17-15(16-18)19-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14,18H,9H2,(H,16,17) |
N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE - Physico-chemical Properties
| Molecular Formula | C15H13NO3 |
| Molar Mass | 255.27 |
| Density | 1.304g/cm3 |
| Melting Point | 164.5°C(lit.) |
| Boling Point | 503.2°C at 760 mmHg |
| Flash Point | 258.2°C |
| Vapor Presure | 6E-11mmHg at 25°C |
| BRN | 7712144 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.634 |
| Physical and Chemical Properties | WGK Germany:3 |
N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
N-(9-FLUORENYLMETYLOXYCARBONYL)-HYDROXYLAMINE - Introduction
9-Fluorenylmethyl N-hydroxycarbamate is a kind of organic compound, chemical name is calcium. It is a compound formed by combining Fmoc protecting group with hydroxylamine group.
9-Fluorenylmethyl N-hydroxycarbamate is commonly used in biochemistry, medicinal chemistry, solid phase synthesis and other fields. As a typical amino acid protection reagent, it can be used to protect the hydroxyl group of amino acid side chain in the synthesis of polypeptides and proteins. In the solvent such as tetrahydrofuran (THF), 9-Fluorenylmethyl N-hydroxycarbamate can be acylated with amino acids to form a stable Fmoc-amino acid ester, which plays the role of protecting amino acids.
The preparation method of 9-Fluorenylmethyl N-hydroxycarbamate is generally obtained by reacting Fmoc-Cl (chloro Fmoc) with hydroxylamine. Usually the reaction will be carried out under basic conditions, for example using sodium carbonate or triiodomethane as the base. The resulting product is finally purified by crystallization or column chromatography.
Regarding the safety information of 9-Fluorenylmethyl N-hydroxycarbamate, it is a chemical and requires necessary protective measures, such as wearing protective glasses and gloves. In addition, avoid contact with skin and eyes during preparation and use, and avoid inhaling its volatiles. In case of any accident or discomfort, seek medical help immediately. Properly store and handle 9-Fluorenylmethyl N-hydroxycarbamate, avoid contact with flammable substances, avoid high temperature and direct sunlight.
9-Fluorenylmethyl N-hydroxycarbamate is commonly used in biochemistry, medicinal chemistry, solid phase synthesis and other fields. As a typical amino acid protection reagent, it can be used to protect the hydroxyl group of amino acid side chain in the synthesis of polypeptides and proteins. In the solvent such as tetrahydrofuran (THF), 9-Fluorenylmethyl N-hydroxycarbamate can be acylated with amino acids to form a stable Fmoc-amino acid ester, which plays the role of protecting amino acids.
The preparation method of 9-Fluorenylmethyl N-hydroxycarbamate is generally obtained by reacting Fmoc-Cl (chloro Fmoc) with hydroxylamine. Usually the reaction will be carried out under basic conditions, for example using sodium carbonate or triiodomethane as the base. The resulting product is finally purified by crystallization or column chromatography.
Regarding the safety information of 9-Fluorenylmethyl N-hydroxycarbamate, it is a chemical and requires necessary protective measures, such as wearing protective glasses and gloves. In addition, avoid contact with skin and eyes during preparation and use, and avoid inhaling its volatiles. In case of any accident or discomfort, seek medical help immediately. Properly store and handle 9-Fluorenylmethyl N-hydroxycarbamate, avoid contact with flammable substances, avoid high temperature and direct sunlight.
Last Update：2024-04-09 20:52:54
