N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline
fmoc-O-tert-butyl-L-hydroxyproline
CAS: 122996-47-8
Molecular Formula: C24H27NO5
N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline - Names and Identifiers
| Name | fmoc-O-tert-butyl-L-hydroxyproline |
| Synonyms | Fmoc-Hyp(tBu)-OH Fmoc-Hyp(But)-OH Fmoc-4-tert-butoxy-L-proline fmoc-O-tert-butyl-L-hydroxyproline trans-N-Fmoc-4-tert-butoxy-L-proline (9H-Fluoren-9-yl)MethOxy]Carbonyl Hyp(tBu)-OH N-ALPHA-FMOC-O-T-BUTYL-L-TRANS-4-HYDROXYPROLINE N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline 4-tert-butoxy-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-proline (4R)-4-tert-butoxy-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-proline N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-trans-(tert-butoxy)-L-proline N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-TRANS-L-HYDROXYPROLINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TERT-BUTYL-TRANS-L-HYDROXYPROLINE |
| CAS | 122996-47-8 |
| InChI | InChI=1/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15?,21-/m0/s1 |
| InChIKey | WPBXBYOKQUEIDW-VFNWGFHPSA-N |
N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline - Physico-chemical Properties
| Molecular Formula | C24H27NO5 |
| Molar Mass | 409.47 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting Point | ~63°C |
| Boling Point | 578.6±50.0 °C(Predicted) |
| Flash Point | 303.7°C |
| Vapor Presure | 3.16E-14mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| BRN | 6161467 |
| pKa | 3.71±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.618 |
| MDL | MFCD00151930 |
N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2933 99 80 |
| Hazard Class | IRRITANT |
N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline - Introduction
Fmoc-4-tert-butoxy-L-proline is an amino acid derivative having the following properties: It is a white or off-white solid, soluble in organic solvents such as methylene chloride and dimethyl sulfoxide. It is poorly soluble in water.
Fmoc-4-tert-butoxy-L-proline is widely used in organic synthesis. It is often used as a reagent to protect the amino group in solid phase synthesis. By connecting the Fmoc group to the amino group, the amino group can be protected from the interference of the reactants, thereby effectively controlling the position selectivity of the synthesis reaction. In the synthesis of peptides and proteins, polypeptide chains can be conveniently synthesized in solid phase synthesis by introducing Fmoc-4-tert-butoxy-L-proline into the sequence.
The Fmoc-4-tert-butoxy-L-proline is generally prepared by reacting Fmoc-aminopropionic acid with L-proline. The specific preparation method can refer to the relevant organic chemical synthesis literature.
Regarding safety information, Fmoc-4-t-butoxy-L-proline is generally considered to be a relatively safe compound, but some basic laboratory safety practices still require attention, such as wearing appropriate protective equipment (such as gloves, masks, goggles, etc.), avoiding direct contact with skin, inhalation of dust or solutions. During use, care should be taken to avoid it from entering the eyes or mouth. When performing large-scale synthesis or use, it should be operated under well-ventilated laboratory conditions.
Fmoc-4-tert-butoxy-L-proline is widely used in organic synthesis. It is often used as a reagent to protect the amino group in solid phase synthesis. By connecting the Fmoc group to the amino group, the amino group can be protected from the interference of the reactants, thereby effectively controlling the position selectivity of the synthesis reaction. In the synthesis of peptides and proteins, polypeptide chains can be conveniently synthesized in solid phase synthesis by introducing Fmoc-4-tert-butoxy-L-proline into the sequence.
The Fmoc-4-tert-butoxy-L-proline is generally prepared by reacting Fmoc-aminopropionic acid with L-proline. The specific preparation method can refer to the relevant organic chemical synthesis literature.
Regarding safety information, Fmoc-4-t-butoxy-L-proline is generally considered to be a relatively safe compound, but some basic laboratory safety practices still require attention, such as wearing appropriate protective equipment (such as gloves, masks, goggles, etc.), avoiding direct contact with skin, inhalation of dust or solutions. During use, care should be taken to avoid it from entering the eyes or mouth. When performing large-scale synthesis or use, it should be operated under well-ventilated laboratory conditions.
Last Update：2024-04-09 20:02:46
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View History
N-(9-Fluorenylmethyloxycarbonyl)-4-tert-butoxy-L-proline
Methyl but-3-enoate
猪去氧胆酸钠盐
1-Pyrenebutyrate
2098496-83-2
Diazabicyclononene (DBN)
1-ADAMANTANECARBOXYLIC ACID CHLOROANHYDRIDE
2-Bromo-4'-methylacetophenone
3H-Pyrazol-3-one,2,4-dihydro-4,4-dihydroxy-5-methyl-(9CI)
蚁酸甲酯
Methyl but-3-enoate
猪去氧胆酸钠盐
1-Pyrenebutyrate
2098496-83-2
Diazabicyclononene (DBN)
1-ADAMANTANECARBOXYLIC ACID CHLOROANHYDRIDE
2-Bromo-4'-methylacetophenone
3H-Pyrazol-3-one,2,4-dihydro-4,4-dihydroxy-5-methyl-(9CI)
蚁酸甲酯