N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE
N-Boc-propargylamine
CAS: 92136-39-5
Molecular Formula: C8H13NO2
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Names and Identifiers
| Name | N-Boc-propargylamine |
| Synonyms | N-Boc-propargylamine N-(tert-Butoxycarbonyl)propargyl amine N-Propargylcarbamic acid tert-butyl ester (2-Propynyl)carbamic acid tert-butyl ester N-prop-2-ynylcarbamic acid tert-butyl ester N-(2-Propynyl)carbamic acid tert-butyl ester N-(2-Propynyl)-carbamic acid tert-butyl ester N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE |
| CAS | 92136-39-5 |
| InChI | InChI=1/C8H13NO2/c1-5-6-9-7(10)11-8(2,3)4/h1H,6H2,2-4H3,(H,9,10) |
| InChIKey | DSPYCWLYGXGJNJ-UHFFFAOYSA-N |
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Physico-chemical Properties
| Molecular Formula | C8H13NO2 |
| Molar Mass | 155.19 |
| Density | 0.990±0.06 g/cm3(Predicted) |
| Melting Point | 40-44 °C |
| Boling Point | 170°C/14mmHg(lit.) |
| Flash Point | 93°(199°F) |
| Solubility | Soluble in chloroform. |
| Vapor Presure | 0.101mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Dark Yellow Low-Melting |
| pKa | 11.24±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.452 |
| MDL | MFCD07367245 |
| Use | Application N-Boc-amino propyne is an organic intermediate, can be used as an intermediate in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process. |
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| WGK Germany | 3 |
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Upstream Downstream Industry
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Preparation
Add (Boc)2O(23.8g,109.1mmol) drop-by-drop to DCM(100mL) solution of prop-2-acetyl-1-amine (5.0g,90.9mmol) and Et3N(18.4g,181.8mmol) cooled by ice bath. After the addition of (Boc)2O is completed, the resulting mixture is warmed to room temperature and stirred at room temperature for 16h. When the reaction is complete, the mixture is diluted with DCM(200mL) and then washed with saline (100mL × 3). The organic layer was dried with Na2SO4 and then concentrated in vacuum. The residue was purified by silica gel column chromatography (PE:EtOAc = 100:1~10:1) to obtain N-Boc-aminopropyne (10g,71%) in a colorless oily form.
Last Update：2024-04-10 22:29:15
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Security information
| WGK Germany | 3 |
Last Update：2024-04-10 22:29:15
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Nature
| storage conditions | 2-8°C |
| solubility | Soluble in chloroform. |
| acidity coefficient (pKa) | 11.24±0.46(Predicted) |
| sensitivity | Moisture Sensitive |
| InChIKey | DSPYCWLYGXGJNJ-UHFFFAOYSA-N |
Last Update：2024-04-09 21:11:58
N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE - Reference Information
| application | N-Boc-aminopropyne is an organic intermediate, which can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
| Preparation | Add (Boc)2O(23.8g,109.1mmol) dropwise to DCM(100mL) solution of prop-2-acetylene-1-amine (5.0g,90.9mmol) and Et3N(18.4g,181.8mmol) cooled by ice bath. After the addition of (Boc)2O is completed, the resulting mixture is warmed to room temperature and stirred at room temperature for 16h. When the reaction is complete, the mixture is diluted with DCM(200mL), and then washed with salt water (100mL × 3). The organic layer was dried with Na2SO4 and then vacuum concentrated. The residue was purified by silica gel column chromatography (PE:EtOAc = 100:1~10:1) to obtain N-Boc-aminopropyne (10g,71%) in a colorless oily form. |
Last Update：2024-04-09 21:31:59
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CAS: 92136-39-5
Tel: 18301782025
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CAS: 92136-39-5
Tel: 18301782025
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View History
Raw Materials for N-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINEN-(tert-BUTOXYCARBONYL)PROPARGYLAMINE
3-Bromopropyne
PROPARGYLAMINE
Carbonic acid, bis(1,1-dimethylethyl) ester
(1-DIAZO-2-OXO-PROPYL)-PHOSPHONIC ACID DIMETHYL ESTER
PROPARGYLAMINE
Carbonic acid, bis(1,1-dimethylethyl) ester
(1-DIAZO-2-OXO-PROPYL)-PHOSPHONIC ACID DIMETHYL ESTER