N-(tert-Butoxycarbonyl)-3-cyclopropylalanine
N-(tert-butoxycarbonyl)-3-cyclopropylalanine
CAS: 888323-62-4
Molecular Formula: C11H19NO4
N-(tert-Butoxycarbonyl)-3-cyclopropylalanine - Names and Identifiers
N-(tert-Butoxycarbonyl)-3-cyclopropylalanine - Physico-chemical Properties
| Molecular Formula | C11H19NO4 |
| Molar Mass | 229.27 |
| Density | 1.162±0.06 g/cm3(Predicted) |
| Boling Point | 377.2±25.0 °C(Predicted) |
| Flash Point | 181.9°C |
| Vapor Presure | 9.93E-07mmHg at 25°C |
| pKa | 4.00±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.498 |
N-(tert-Butoxycarbonyl)-3-cyclopropylalanine - Introduction
N-(tert-butoxycarbonyl)-3-cyclopylalanine (N-(tert-butoxycarbonyl)-3-cyclopylalanine) is a chemical substance whose properties are as follows:
1. Appearance: White crystalline solid.
2. molecular formula: C13H19NO4.
3. Molecular weight: 261.29g/mol.
4. Melting point: about 140-145°C.
5. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
The application of N-(tert-butoxycarbonyl)-3-cyclopylalanine in organic synthesis is as follows:
1. Drug synthesis: As an unnatural amino acid, it is often used in the synthesis of peptide compounds and drugs.
2. research tools: used to study protein structure and biological activity, such as the synthesis of new peptide antibacterial agents and receptor agonists.
Preparation of N-(tert-butoxycarbonyl)-3-cyclopylalanine:
A common preparation method is to synthesize its derivatives by protecting alanine and cyclopropylating. Specific methods are as follows:
1.3-Alanine was reacted with tert-butoxycarbonyl cuprous chloride (CuCl(OBt)) in chloroform solvent.
2. Add triethylamine to neutralize the reaction system.
3. The obtained mixture was purified by distillation to obtain the target product.
Safety Information:
1. N-(tert-butoxycarbonyl)-3-cyclopylalanine should be used and stored to avoid inhalation, intake and skin contact. Wear protective equipment such as chemical protective gloves and goggles.
2. in the operation should maintain a well-ventilated environment.
3. should be stored in a cool, dry and well-ventilated place.
1. Appearance: White crystalline solid.
2. molecular formula: C13H19NO4.
3. Molecular weight: 261.29g/mol.
4. Melting point: about 140-145°C.
5. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
The application of N-(tert-butoxycarbonyl)-3-cyclopylalanine in organic synthesis is as follows:
1. Drug synthesis: As an unnatural amino acid, it is often used in the synthesis of peptide compounds and drugs.
2. research tools: used to study protein structure and biological activity, such as the synthesis of new peptide antibacterial agents and receptor agonists.
Preparation of N-(tert-butoxycarbonyl)-3-cyclopylalanine:
A common preparation method is to synthesize its derivatives by protecting alanine and cyclopropylating. Specific methods are as follows:
1.3-Alanine was reacted with tert-butoxycarbonyl cuprous chloride (CuCl(OBt)) in chloroform solvent.
2. Add triethylamine to neutralize the reaction system.
3. The obtained mixture was purified by distillation to obtain the target product.
Safety Information:
1. N-(tert-butoxycarbonyl)-3-cyclopylalanine should be used and stored to avoid inhalation, intake and skin contact. Wear protective equipment such as chemical protective gloves and goggles.
2. in the operation should maintain a well-ventilated environment.
3. should be stored in a cool, dry and well-ventilated place.
Last Update：2024-04-09 02:00:48
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Product Name: N-BOC-CYCLOPROPYL-DL-ALANINE Visit Supplier Webpage Request for quotation
CAS: 888323-62-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 888323-62-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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