N-(tert-butoxycarbonyl)-L-prolinal
N-(tert-butoxycarbonyl)-L-prolinal
CAS: 69610-41-9
Molecular Formula: C10H17NO3
N-(tert-butoxycarbonyl)-L-prolinal - Names and Identifiers
| Name | N-(tert-butoxycarbonyl)-L-prolinal |
| Synonyms | Boc-L-Pro-H BOC-L-PROLINAL N-BOC-L-PROLINAL N-Boc-L-prolinal (S)-N-BOC-Prolinal (S)-Boc-pyrrolidine-2-carbaldehyde N-(tert-butoxycarbonyl)-L-prolinal (S)-tert-Butyl 2-formylpyrrolidine-1-carboxylate (S)-tert-butyl 2-formylpyrrolidine-1-carboxylate tert-butyl (2R)-2-formylpyrrolidine-1-carboxylate tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate 2-Formylpyrrolidine-1-carboxylic acid tert-butyl ester (S)-N-Boc-pyrrolidine-2-carboxaldehyde, N-(tert-Butoxycarbonyl)-L-prolinal |
| CAS | 69610-41-9 |
| EINECS | 627-548-9 |
| InChI | InChI=1/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1 |
| InChIKey | YDBPZCVWPFMBDH-QMMMGPOBSA-N |
N-(tert-butoxycarbonyl)-L-prolinal - Physico-chemical Properties
| Molecular Formula | C10H17NO3 |
| Molar Mass | 199.25 |
| Density | 1.063 g/mL at 25 °C (lit.) |
| Boling Point | 211 °C (lit.) |
| Specific Rotation(α) | -101 º (c=0.66 in chloroform) |
| Flash Point | 135°F |
| Water Solubility | Slightly soluble water. Soluble in chloroform. |
| Vapor Presure | 0.00483mmHg at 25°C |
| Appearance | Yellow Viscous Liquid |
| Specific Gravity | 1.063 |
| pKa | -3.03±0.40(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.462(lit.) |
| MDL | MFCD00274186 |
| Use | An important structural unit for the carbon skeleton of a descending securinine alkaloid and an indigo diketone. |
N-(tert-butoxycarbonyl)-L-prolinal - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 1989 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
N-(tert-butoxycarbonyl)-L-prolinal - Introduction
N-(tert-butoxycarbonyl)-L-prolinal, chemically known as N-(tert-butoxycarbonyl)-L-prolinal, is an organic compound. Its physical properties are white crystalline solid, melting point at 88-90°C, and its chemical formula is C11H17NO3.
N-(tert-butoxycarbonyl)-L-prolinal is commonly used as a protecting group for amino acid derivatives for the synthesis of peptides and drugs. It can protect amino and carboxyl groups in amino acids and provide a stable state of protection to prevent them from unwanted reactions in chemical reactions. In the synthesis of polypeptides, it is often used as the starting amino acid in solid phase synthesis.
The preparation method of N-(tert-butoxycarbonyl)-L-prolinal is relatively simple, usually by acylation of amino acids. Specifically, L-prolinol and Boc-OSu are reacted to obtain N-(tert-butoxycarbonyl)-L-prolinal.
Regarding safety information, N-(tert-butoxycarbonyl)-L-prolinal can be considered relatively safe compounds under normal circumstances. However, as an organic compound, it should follow basic safety practices, such as wearing protective glasses and gloves, avoiding contact with skin and inhalation. It should be stored in a dry, cool place and away from open flames and oxidants. During use, if contact or inhalation occurs, seek medical attention immediately.
N-(tert-butoxycarbonyl)-L-prolinal is commonly used as a protecting group for amino acid derivatives for the synthesis of peptides and drugs. It can protect amino and carboxyl groups in amino acids and provide a stable state of protection to prevent them from unwanted reactions in chemical reactions. In the synthesis of polypeptides, it is often used as the starting amino acid in solid phase synthesis.
The preparation method of N-(tert-butoxycarbonyl)-L-prolinal is relatively simple, usually by acylation of amino acids. Specifically, L-prolinol and Boc-OSu are reacted to obtain N-(tert-butoxycarbonyl)-L-prolinal.
Regarding safety information, N-(tert-butoxycarbonyl)-L-prolinal can be considered relatively safe compounds under normal circumstances. However, as an organic compound, it should follow basic safety practices, such as wearing protective glasses and gloves, avoiding contact with skin and inhalation. It should be stored in a dry, cool place and away from open flames and oxidants. During use, if contact or inhalation occurs, seek medical attention immediately.
Last Update：2024-04-09 20:45:29
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View History
N-(tert-butoxycarbonyl)-L-prolinal
N,a-Dimethylphenethylamine hydrochloride
盐酸雷洛昔芬
1H-Imidazole,1-methyl-2-[[(tetrahydro-2H-pyran-2-yl)methyl]thio]-(9CI)
4-phenoxypropiophenone
Amino-1,2-propanediol, (S)-3-
1H-Indole, 4-methyl-
70769-76-5
9-苯蒽
N-ACYL-L-AMINO-ACID AMIDOHYDROLASE
N,a-Dimethylphenethylamine hydrochloride
盐酸雷洛昔芬
1H-Imidazole,1-methyl-2-[[(tetrahydro-2H-pyran-2-yl)methyl]thio]-(9CI)
4-phenoxypropiophenone
Amino-1,2-propanediol, (S)-3-
1H-Indole, 4-methyl-
70769-76-5
9-苯蒽
N-ACYL-L-AMINO-ACID AMIDOHYDROLASE