N-6-carbobenzyloxy-L-lysine
N-epsilon-Carbobenzyloxy-L-lysine
CAS: 1155-64-2
Molecular Formula: C14H20N2O4
N-6-carbobenzyloxy-L-lysine - Names and Identifiers
| Name | N-epsilon-Carbobenzyloxy-L-lysine |
| Synonyms | LYS(Z) Lys(z) H-Lys(Z)-OH H-LYS(Z)-OH Z-(e)-Lysine LYSINE(Z)-OH H-LYS(CBZ)-OH L-LYSINE(CBZ) N6-Cbz-L-lysine N-epsilon-CBZ-L-Lysine BenzyloxycarbonylLlysine N6-Carbobenzyloxy-L-lysine N-6-carbobenzyloxy-L-lysine EPSILON-CARBOBENZOXY-L-LYSINE N6-benzyloxycarbonyl-L-lysine N(5)-Benzyloxycarbonyl-L-lysine N-epsilon-Carbobenzyloxy-L-lysine N~2~-[(benzyloxy)carbonyl]-L-lysine N-?-CBZ-L-Lysine N-?-Carbobenzyloxy-L-lysine (2S)-2-ammonio-6-{[(benzyloxy)carbonyl]amino}hexanoate |
| CAS | 1155-64-2 |
| EINECS | 214-585-7 |
| InChI | InChI=1/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1 |
N-6-carbobenzyloxy-L-lysine - Physico-chemical Properties
| Molecular Formula | C14H20N2O4 |
| Molar Mass | 280.32 |
| Density | 1.1429 (rough estimate) |
| Melting Point | 259°C (dec.)(lit.) |
| Boling Point | 423.04°C (rough estimate) |
| Specific Rotation(α) | 14.4 º (c=1.6 in 1N HCl) |
| Flash Point | 255.9°C |
| Solubility | Aqueous Base, Dilute Acid |
| Vapor Presure | 8.43E-11mmHg at 25°C |
| Appearance | White to off-white powder |
| Color | White to off-white |
| BRN | 2222482 |
| pKa | 2.53±0.24(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 16 ° (C=1.6, 2mol/L |
| MDL | MFCD00002638 |
N-6-carbobenzyloxy-L-lysine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
N-6-carbobenzyloxy-L-lysine - Introduction
Soluble in most conventional organic solvents.
Last Update：2022-10-16 17:12:22
N-6-carbobenzyloxy-L-lysine - Reference Information
| introduction | N6-Cbz-L-lysine is a white to off-white solid powder under normal temperature and pressure. it is an amino acid derivative and an intermediate in chiral organic synthesis. N6-Cbz-L-lysine has very poor solubility in ether solvents. ether solvents are often used as undesirable solvents in relevant literature to precipitate N6-Cbz-L-lysine target products. |
| Uses | N6-Cbz-L-lysine is an amino acid derivative and an intermediate in chiral organic synthesis. Its main purpose is to participate as a molecular skeleton in the synthesis of chiral drug molecules and biologically active molecules. In addition, the carboxyl group in N6-Cbz-L-lysine can undergo esterification in the presence of an amino group. The ester group protected by benzyl in the molecular structure can be easily removed under acidic conditions, releasing free carboxyl groups. |
| Synthesis route | For the synthesis of N6-Cbz-L-lysine, the conventional synthesis method is from the lysine of its corresponding configuration and the acid chloride of another fragment Starting from the reaction of the amino group and the acid chloride to generate the corresponding amide to obtain the target product N6-Cbz-L-lysine. This route requires the addition of alkali as an acid binding agent, such as sodium hydroxide. |
| environmental hazards | as an organic amine, N6-Cbz-L-lysine is harmful to the water environment and cannot allow undiluted or large amounts of products to contact groundwater, waterways or sewage systems. |
Last Update：2024-04-09 20:52:54
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