N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE
Fmoc-Arg(Boc)2-OH
CAS: 143824-77-5
Molecular Formula: C31H40N4O8
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE - Names and Identifiers
| Name | Fmoc-Arg(Boc)2-OH |
| Synonyms | FMOC-ARG(BOC)2-OH Fmoc-Arg(Boc)2-OH FMOC-L-ARG(BOC)2-OH FMOC-ARGININE(BOC)2-OH N-ALPHA-FMOC-NG,NG-DIBOC-L-ARGININE FMOC-N-OMEGA,N-OMEGA'-BIS-BOC-L-ARGININE N-ALPHA-FMOC-N-OMEGA,N-OMEGA'-BIS-T-BUTOXYCARBONYL-L-ARGININE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N',N''-BIS-TERT-BUTYLOXYCARBONYL-L-ARGININE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-N~5~-(2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)-L-ornithine |
| CAS | 143824-77-5 |
| InChI | InChI=1/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1 |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE - Physico-chemical Properties
| Molecular Formula | C31H40N4O8 |
| Molar Mass | 596.67 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Appearance | Solid |
| pKa | 3.80±0.21(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.581 |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE - Introduction
Fmoc-Arg(Boc)2-OH(N-Fmoc-N, N''-diBoc-L-arginine) is a common amino acid derivative, which is widely used in peptide synthesis and solid phase synthesis in chemical synthesis.
Nature:
Fmoc-Arg(Boc)2-OH is a white solid, soluble in organic solvents. It has two protecting groups in its structure: Fmoc and Boc. The Fmoc group protects the amino group and needs to be removed by alkali treatment. The Boc Group protects the two amino groups in arginine and can be removed by acid treatment.
Use:
Fmoc-Arg(Boc)2-OH is widely used in solid phase synthesis and peptide synthesis. In solid phase synthesis, it can be linked as an amino acid unit with other amino acids to construct a specific peptide sequence. In peptide synthesis, it is usually used as a temporary protecting group to protect the amino group of arginine, and the protecting group is removed after the synthesis is completed.
Method:
The preparation method of Fmoc-Arg(Boc)2-OH is relatively complicated, and is generally completed by multi-step organic synthesis. Its synthesis often uses L-arginine as the starting material, and Fmoc and Boc protecting groups are introduced sequentially through chemical reactions.
Safety Information:
Fmoc-Arg(Boc)2-OH generally does not have obvious toxicity, but it is still necessary to pay attention to safety measures during operation, such as wearing personal protective equipment required by the laboratory, avoiding contact with eyes, skin and taking. During storage and handling, keep dry and avoid contact with acid or alkali to avoid violent reaction. In certain cases, specific safety operations are to be carried out in accordance with the actual Material Safety Data Sheet (MSDS).
Nature:
Fmoc-Arg(Boc)2-OH is a white solid, soluble in organic solvents. It has two protecting groups in its structure: Fmoc and Boc. The Fmoc group protects the amino group and needs to be removed by alkali treatment. The Boc Group protects the two amino groups in arginine and can be removed by acid treatment.
Use:
Fmoc-Arg(Boc)2-OH is widely used in solid phase synthesis and peptide synthesis. In solid phase synthesis, it can be linked as an amino acid unit with other amino acids to construct a specific peptide sequence. In peptide synthesis, it is usually used as a temporary protecting group to protect the amino group of arginine, and the protecting group is removed after the synthesis is completed.
Method:
The preparation method of Fmoc-Arg(Boc)2-OH is relatively complicated, and is generally completed by multi-step organic synthesis. Its synthesis often uses L-arginine as the starting material, and Fmoc and Boc protecting groups are introduced sequentially through chemical reactions.
Safety Information:
Fmoc-Arg(Boc)2-OH generally does not have obvious toxicity, but it is still necessary to pay attention to safety measures during operation, such as wearing personal protective equipment required by the laboratory, avoiding contact with eyes, skin and taking. During storage and handling, keep dry and avoid contact with acid or alkali to avoid violent reaction. In certain cases, specific safety operations are to be carried out in accordance with the actual Material Safety Data Sheet (MSDS).
Last Update：2024-04-09 02:00:42
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CAS: 143824-77-5
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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