N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
boc-N-methyl-L-leucine
CAS: 53363-89-6
Molecular Formula: C12H23NO4
N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE - Names and Identifiers
| Name | boc-N-methyl-L-leucine |
| Synonyms | Boc-N-Me-Leu-OH BOC-BETA-TBU-ALA-OH BOC-BETA-TBU-ALANINE boc-N-methyl-L-leucine N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE N-(tert-butoxycarbonyl)-N-methylleucine N-(tert-butoxycarbonyl)-N-methyl-L-leucine N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE N-alpha-t-butyloxycabonyl-N-alpha-Methyl-L-leucine N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE |
| CAS | 53363-89-6 |
| InChI | InChI=1/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1 |
| InChIKey | YXJFAOXATCRIKU-VIFPVBQESA-N |
N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE - Physico-chemical Properties
| Molecular Formula | C12H23NO4 |
| Molar Mass | 245.32 |
| Density | 1.053±0.06 g/cm3(Predicted) |
| Melting Point | 55-60°C |
| Boling Point | 338.2±21.0 °C(Predicted) |
| Flash Point | 158.3°C |
| Vapor Presure | 1.86E-05mmHg at 25°C |
| BRN | 2373250 |
| pKa | 4.04±0.21(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.466 |
N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2924 19 00 |
| Hazard Class | IRRITANT |
N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE - Introduction
boc-N-methyl-L-leucine(boc-N-methyl-L-leucine) is an amino acid derivative. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White or off-white solid;
-Molecular formula: C14H27NO4;
-Molecular weight: 273.37g/mol;
-Melting point: 52-54°C;
-Solubility: insoluble in water, soluble in organic solvents such as alcohol and ether;
-Density: about 1.072g/cm³.
Use:
- boc-N-methyl-L-leucine are commonly used as intermediates in drug synthesis and peptide synthesis;
-In drug research, it can be used as an amino acid derivative to change the properties and activity of drug molecules;
-In polypeptide synthesis, it can be used as a protecting group to protect the hydroxyl group on the leucine side chain, so as to avoid accidental modification during the synthesis process.
Preparation Method:
boc-N-methyl-L-leucine can be prepared by the following steps:
1. First, N-tert-butoxycarbonyl-L-leucine is reacted with methanol, and the methylation reaction is carried out in the presence of a base;
2. Subsequently, the protecting group tert-butyloxycarbonyl group in the product is lost under acid catalysis to obtain boc-N-methyl-L-leucine.
Safety Information:
-The boc-N-methyl-L-leucine is generally relatively safe under normal operating conditions;
-However, because it is a chemical substance, appropriate safety measures must be taken, including wearing appropriate personal protective equipment (such as laboratory gloves and eye protection glasses);
-Avoid contact with skin and inhalation;
-If contact with skin or discomfort occurs, rinse immediately with plenty of water.
-When using and storing, please observe the relevant chemical safety practices.
Nature:
-Appearance: White or off-white solid;
-Molecular formula: C14H27NO4;
-Molecular weight: 273.37g/mol;
-Melting point: 52-54°C;
-Solubility: insoluble in water, soluble in organic solvents such as alcohol and ether;
-Density: about 1.072g/cm³.
Use:
- boc-N-methyl-L-leucine are commonly used as intermediates in drug synthesis and peptide synthesis;
-In drug research, it can be used as an amino acid derivative to change the properties and activity of drug molecules;
-In polypeptide synthesis, it can be used as a protecting group to protect the hydroxyl group on the leucine side chain, so as to avoid accidental modification during the synthesis process.
Preparation Method:
boc-N-methyl-L-leucine can be prepared by the following steps:
1. First, N-tert-butoxycarbonyl-L-leucine is reacted with methanol, and the methylation reaction is carried out in the presence of a base;
2. Subsequently, the protecting group tert-butyloxycarbonyl group in the product is lost under acid catalysis to obtain boc-N-methyl-L-leucine.
Safety Information:
-The boc-N-methyl-L-leucine is generally relatively safe under normal operating conditions;
-However, because it is a chemical substance, appropriate safety measures must be taken, including wearing appropriate personal protective equipment (such as laboratory gloves and eye protection glasses);
-Avoid contact with skin and inhalation;
-If contact with skin or discomfort occurs, rinse immediately with plenty of water.
-When using and storing, please observe the relevant chemical safety practices.
Last Update：2024-04-09 21:01:54
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CAS: 53363-89-6
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QQ: 3008007409
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CAS: 53363-89-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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