N-ALPHA-Z-L-HISTIDINE
N(alpha)-Z-L-histidine
CAS: 14997-58-1
Molecular Formula: C14H15N3O4
N-ALPHA-Z-L-HISTIDINE - Names and Identifiers
| Name | N(alpha)-Z-L-histidine |
| Synonyms | Z-His Z-His-OH Cbz-L-histidine N-Cbz-L-histidine CBZ-L-Histidine-OH N-ALPHA-Z-L-HISTIDINE N(alpha)-Z-L-histidine N(ALPHA)-CBZ-L-HISTIDINE N(alpha)-Cbz-L-histidine N-CARBOBENZOXY-L-HISTIDINE N2-CARBOBENZYLOXY-L-HISTIDINE NALPHA-CARBOBENZOXY-L-HISTIDINE N-Benzyloxycarbonyl-L-histidine N-[(benzyloxy)carbonyl]histidine N-(alpha)-Carbobenzoxy-L-histidine N-alpha-carbobenzyloxy-L-histidine N-ALPHA-CARBOBENZYLOXY-L-HISTIDINE NALPHA-Benzyloxycarbonyl-L-histidine N-ALPHA-BENZYLOXYCARBONYL-L-HISTIDINE N(alpha)-Benzyloxycarbonyl-L-histidine~Z-His-OH (S)-2-BENZYLOXYCARBONYLAMINO-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID |
| CAS | 14997-58-1 |
| EINECS | 239-084-0 |
| InChI | InChI=1/C14H15N3O4/c18-13(19)12(6-11-7-15-9-16-11)17-14(20)21-8-10-4-2-1-3-5-10/h1-5,7,9,12H,6,8H2,(H,15,16)(H,17,20)(H,18,19)/t12-/m0/s1 |
| InChIKey | WCOJOHPAKJFUDF-LBPRGKRZSA-N |
N-ALPHA-Z-L-HISTIDINE - Physico-chemical Properties
| Molecular Formula | C14H15N3O4 |
| Molar Mass | 289.29 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Melting Point | 168°C (dec.)(lit.) |
| Boling Point | 616.7±55.0 °C(Predicted) |
| Specific Rotation(α) | -24 º (c=1 in 6 M HCl) |
| Flash Point | 326.8°C |
| Water Solubility | almost transparency |
| Vapor Presure | 4.56E-16mmHg at 25°C |
| Appearance | White to off-white microcrystalline powder |
| Color | White to Almost white |
| BRN | 3561682 |
| pKa | 3.35±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | -23.5 ° (C=6, 6mol/L |
| MDL | MFCD00065960 |
N-ALPHA-Z-L-HISTIDINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29332900 |
N-ALPHA-Z-L-HISTIDINE - Introduction
N(alpha)-Z-L-histidine is an organic compound with the chemical name benzyl N-methyliminate-α-hydroxypropionate. It belongs to amino acid derivatives.
N(alpha)-The nature of the Z-L-histidine:
-Appearance: White crystalline powder
-Molecular formula: C12H15NO4
-Molecular weight: 233.25g/mol
-Melting point: 90-94 ° C
-Solubility: Soluble in ethanol, chloroform and dimethyl sulfoxide and other organic solvents, insoluble in water.
N(alpha)-Z-L-histidine use:
- N(alpha)-Z-L-histidine, as an important intermediate in organic synthesis, is widely used in the fields of medicine, pesticide and cosmetics.
-it can be used for the synthesis of procaine esters of local anesthetics, carbamine and other drugs.
- N(alpha)-Z-L-histidine can also be used to synthesize biologically active polypeptide compounds, such as synthetic peptide antibiotics.
N(alpha)-Z-L-histidine preparation method:
N(alpha)-Z-L-histidine is prepared by reacting L-histidine with chloromethyl formate to produce N(alpha)-Z-L-histidine formate, the N(alpha)-Z-L-histidine is then obtained by acid hydrolysis.
N(alpha)-Z-L-histidine security information:
- N(alpha)-Z-L-histidine are generally stable under normal conditions of use, but avoid contact with strong oxidants.
-Wear appropriate personal protective equipment when using to avoid inhalation or contact with skin and eyes.
-Keep away from fire and high temperature during use and storage.
-Before use, it is best to read the product safety data sheet to understand its specific safety operating requirements.
N(alpha)-The nature of the Z-L-histidine:
-Appearance: White crystalline powder
-Molecular formula: C12H15NO4
-Molecular weight: 233.25g/mol
-Melting point: 90-94 ° C
-Solubility: Soluble in ethanol, chloroform and dimethyl sulfoxide and other organic solvents, insoluble in water.
N(alpha)-Z-L-histidine use:
- N(alpha)-Z-L-histidine, as an important intermediate in organic synthesis, is widely used in the fields of medicine, pesticide and cosmetics.
-it can be used for the synthesis of procaine esters of local anesthetics, carbamine and other drugs.
- N(alpha)-Z-L-histidine can also be used to synthesize biologically active polypeptide compounds, such as synthetic peptide antibiotics.
N(alpha)-Z-L-histidine preparation method:
N(alpha)-Z-L-histidine is prepared by reacting L-histidine with chloromethyl formate to produce N(alpha)-Z-L-histidine formate, the N(alpha)-Z-L-histidine is then obtained by acid hydrolysis.
N(alpha)-Z-L-histidine security information:
- N(alpha)-Z-L-histidine are generally stable under normal conditions of use, but avoid contact with strong oxidants.
-Wear appropriate personal protective equipment when using to avoid inhalation or contact with skin and eyes.
-Keep away from fire and high temperature during use and storage.
-Before use, it is best to read the product safety data sheet to understand its specific safety operating requirements.
Last Update：2024-04-09 21:32:37
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