N-Acetyl-3,4,5-trifluoro-D-phenylalanine
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid
CAS: 324028-12-8
Molecular Formula: C11H10F3NO3
N-Acetyl-3,4,5-trifluoro-D-phenylalanine - Names and Identifiers
| Name | (2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid |
| Synonyms | LogP N-Acetyl-3,4,5-trifluoro-D-phenylalanine D-Phenylalanine, N-acetyl-3,4,5-trifluoro- N-ACETYL-3-(3,4,5-TRIFLUOROPHENYL)-D-ALANINE (R)-2-Acetamido-3-(3,4,5-trifluorophenyl)propanoic acid (2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid (R)-(3,4,5-trifluoro-phenyl)-2-AcetylaMino-propionic acid (R)-2-Acetylamino-3-(3,4,5-trifluoro-phenyl)-propionic acid |
| CAS | 324028-12-8 |
| InChI | InChI=1/C11H10F3NO3/c1-5(16)15-9(11(17)18)4-6-2-7(12)10(14)8(13)3-6/h2-3,9H,4H2,1H3,(H,15,16)(H,17,18)/t9-/m1/s1 |
N-Acetyl-3,4,5-trifluoro-D-phenylalanine - Physico-chemical Properties
| Molecular Formula | C11H10F3NO3 |
| Molar Mass | 261.2 |
| Density | 1.409g/cm3 |
| Boling Point | 446.7°C at 760 mmHg |
| Flash Point | 223.9°C |
| Vapor Presure | 9.23E-09mmHg at 25°C |
| Refractive Index | 1.503 |
N-Acetyl-3,4,5-trifluoro-D-phenylalanine - Introduction
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid is an organic compound with the chemical formula C11H10F3NO3. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: colorless crystal
-Melting Point: 156-158 ° C
-Molecular weight: 263.19g/mol
-Solubility: Soluble in ethanol, chloroform and other organic solvents
Use:
- (2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid may be used as a pharmaceutical intermediate. Due to the particularity of its chemical structure and stereo configuration, it may play a key role in the synthesis of some compounds.
Method: The preparation method of
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid is more complicated, and a possible synthetic route is as follows:
1. Chloroacetone is reacted with (3,4, 5-trifluorophenyl) ethanol to obtain (3,4, 5-trifluorophenyl)-2-n-acetylacetone.
2. (3,4, 5-trifluorophenyl)-2-n-acetylacetone reacts with threonine to obtain the target product through reduction, acylation and other steps.
Safety Information:
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid is a chemical reagent, which needs to be used in accordance with relevant laboratory safety operation specifications.
-Avoid contact with skin, eyes, and respiratory tract. If contact occurs, rinse immediately with plenty of water and seek medical attention in time.
-Store in a dry, well-ventilated place, away from fire and oxidizing agents.
-Avoid inhaling dust or solution vapors. It is recommended to wear appropriate protective equipment such as gloves and protective glasses during operation.
Please note that when using or handling any chemical substance, it is necessary to fully understand the relevant information in advance and follow appropriate safety practices.
Nature:
-Appearance: colorless crystal
-Melting Point: 156-158 ° C
-Molecular weight: 263.19g/mol
-Solubility: Soluble in ethanol, chloroform and other organic solvents
Use:
- (2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid may be used as a pharmaceutical intermediate. Due to the particularity of its chemical structure and stereo configuration, it may play a key role in the synthesis of some compounds.
Method: The preparation method of
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid is more complicated, and a possible synthetic route is as follows:
1. Chloroacetone is reacted with (3,4, 5-trifluorophenyl) ethanol to obtain (3,4, 5-trifluorophenyl)-2-n-acetylacetone.
2. (3,4, 5-trifluorophenyl)-2-n-acetylacetone reacts with threonine to obtain the target product through reduction, acylation and other steps.
Safety Information:
(2R)-2-acetamido-3-(3,4,5-trifluorophenyl)propanoic acid is a chemical reagent, which needs to be used in accordance with relevant laboratory safety operation specifications.
-Avoid contact with skin, eyes, and respiratory tract. If contact occurs, rinse immediately with plenty of water and seek medical attention in time.
-Store in a dry, well-ventilated place, away from fire and oxidizing agents.
-Avoid inhaling dust or solution vapors. It is recommended to wear appropriate protective equipment such as gloves and protective glasses during operation.
Please note that when using or handling any chemical substance, it is necessary to fully understand the relevant information in advance and follow appropriate safety practices.
Last Update：2024-04-09 21:04:16
