N-Acetyl-L-Cysteine
N-Acetyl-L-cysteine
CAS: 616-91-1
Molecular Formula: C5H9NO3S
N-Acetyl-L-Cysteine - Names and Identifiers
N-Acetyl-L-Cysteine - Physico-chemical Properties
| Molecular Formula | C5H9NO3S |
| Molar Mass | 163.19 |
| Density | 1.249 (estimate) |
| Melting Point | 106-108°C(lit.) |
| Boling Point | 407.7±40.0 °C(Predicted) |
| Specific Rotation(α) | -35.1 ºC (c=2,H2O) |
| Flash Point | 200.4°C |
| Water Solubility | Soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether. |
| Solubility | Soluble in water and ethanol |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | White crystal |
| Color | White |
| Merck | 14,88 |
| BRN | 1724426 |
| pKa | pK1: 9.52 (30°C) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 24 ° (C=JPC Method) |
| MDL | MFCD00004880 |
| Physical and Chemical Properties | N-acetyl-L-cysteine white crystalline powder with garlic-like odor, sour. Hygroscopic, soluble in water or ethanol, insoluble in ether, chloroform. In aqueous solution was acidic (10g/L H2O pH2-2.75),mp101-107. This product is an N-acetylated derivative of cysteine, containing sulfhydryl group in the molecule, which can break the disulfide bond (-S-S-) of the mucin peptide bond, thus turning the mucin chain into a small molecule peptide chain, reduce the viscosity of mucin, therefore, this product is mucilaginous, purulent sputum, respiratory tract mucus dissolution drugs. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| Target | ROS/ROS1 TNF-α |
N-Acetyl-L-Cysteine - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | HA1660000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29309016 |
| Toxicity | LD50 orally in rats: 5050 mg/kg (Goldenthal) |
N-Acetyl-L-Cysteine - Reference
| Reference Show more | 1. Li Liangcai, Zhao Feifei, Wang Min, etc. Protective effect of Andrographolide sulfate on acetaminophen-induced acute liver injury in mice [J]. Natural product research and development, 2018(5). 2. Cheng Ke, Yan Jun, Yan Xiaoxue, etc. Processing quality characteristics and antioxidant activity evaluation of different varieties of blueberry juice in Hubei area [J]. Food and Fermentation Industry, 2020, 046(009):146-151. 3. Wang Xiaojie, I buy Erjiang · yaohufu, Alim hot · bumetti, Han Juncheng, Yang Li, Xia lining, safiding · aburah, Cahar · SimaYi. Screening of protective effects of chicory polysaccharide on drug-induced liver injury in mice [J]. Modern animal husbandry and veterinary medicine, 2021(04):9-13. 4. Zousi, Yi Jun, Wu Yanbin, Wu Jinzhong, Wu Jianguo. Protective effect of aqueous extract of Sclerotium of Sclerotium of Pleurotus ostreatus on acetaminophen-induced acute liver injury in mice [J]. Chinese Journal of edible fungi, 2020,27(04):85-90. 5. Guizi Peng, Xin Pan, Haiyan Hu, Yuehong Xu, Chuanbin Wu, N-terminal site-specific pegyration implications the circulation half-life of Thymosin alpha 1, Journal of Drug Delivery Science and Technology, Volume 49, 2019, Pages 405-412, ISSN 1773-2247, https://do 6. [IF=7.46] Yao Fan et al."Nanoporphyrin/CdTe quantum dots: A robust tool for effective differentiation among DNA structures."Sensor Actuat B- Chem. 2019 Feb;281:623 7. [IF=4.142] Ma Xiaohan et al."VS2 quantum dot label-free fluorescent probe for sensitive and selective detection of ALP."Anal Bioanal Chem. 2018 Feb;410(5):1417-1426 8. [IF=3.981] Guizi Peng et al."N-terminal site-specific PEGylation enhances the circulation half-life of Thymosin alpha 1."J Drug Deliv Sci Tec. 2019 Feb;49:405 9. [IF=7.46] Li Liu et al."“Turn off-on” fluorescent sensor based on quantum dots and self-assembled porphyrin for rapid detection of ochratoxin A."Sensor Actuat B- Chem. 2020 Jan;302:127212 10. [IF=6.895] Yuan Zhuang et al."Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death."Nanoscale. 2020 Jan;12(3):1389-1396 11. [IF=6.543] Gong Wan et al."Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway."Oxidative Medicine and Cellular Longevity. 2022;2022:5410377 12. [IF=3.361] Bingchen Han et al."The fluorescence mechanism of carbon dots based on the separation and identification of small molecular fluorophores."RSC Advances. 2022 Apr;12(19):11640-11648 |
N-Acetyl-L-Cysteine - Nature
Open Data Verified Data
- This product is a white crystalline powder; Similar to the garlic odor, acid; There is a hygroscopicity. Soluble in water or ethanol. The melting point was 101-107 °c.
- This product is an N-acetylated cysteine, and the sulfhydryl group (-SH) contained in the molecule can break the disulfide bond (-S- S-) connecting the mucin peptide chain in the sputum, mucin into a small molecule of the peptide chain, reduce the viscosity of sputum; It can also make the purulent sputum DNA fiber breakage, it can not only dissolve white phlegm but also can dissolve purulent sputum.
Last Update：2024-01-02 23:10:35
N-Acetyl-L-Cysteine - Standard
Authoritative Data Verified Data
This product is N-acetyl-L-cysteine. The content of C5H9N03S shall be 98.0%-102.0% calculated as dry.
Last Update：2024-01-02 23:10:35
N-Acetyl-L-Cysteine - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Has similar garlic odor; Has hygroscopicity.
- This product is soluble in water or ethanol.
melting point
The melting point of this product (General 0612) is 104~110°C.
specific rotation
take this product about 2.5g, precision weighing, add ethylenediamine tetraacetic acid disodium solution (l-100)2ml and sodium hydroxide test solution (4-100)15ml to dissolve, with phosphate buffer (pH 7.0) A solution containing about 50mg per 1ml was prepared by quantitative dilution and measured according to law (General 0621), and the specific rotation was 21.0 ° to 27.0 °.
Last Update：2022-01-01 11:29:12
N-Acetyl-L-Cysteine - Introduction
Antioxidants and mucolytic agents. Free radical capture agents that increase the cell bank. N-acetylcysteine has been reported to prevent neuronal apoptosis but induce apoptosis in smooth muscle cells. Inhibition of HIV replication. It can be used as a substrate for microsomal glutathione transferase. Acetylcysteine(N-acetyl-l-cysteine) is an ROS inhibitor that antagonizes the activity of various proteasome inhibitors. It is also an inhibitor of tumor necrosis factor TNF and is mainly used as an expectorant to treat paracetamol (acetaminophen) overdose.
Last Update：2022-10-16 17:27:10
N-Acetyl-L-Cysteine - Use
Open Data Verified Data
phlegm dissolving drug. Applicable to a large number of phlegm caused by Dyspnea. It can be used for detoxification of acetaminophen poisoning. The formulation has a spray. Usage, dosage and emergency situation, use 10% solution spray inhalation, 1 ~ 3mL each time, 2~3 times a day; Tracheal instillation: tracheal intubation with 5% solution or direct instillation into the trachea during emergency treatment, 1 ~ 2mL each time, 2~6 times a day; Tracheal injection: in first aid, inject 0.5 ~ 2mL solution into tracheal cavity with syringe from tracheal thyroid perichondrium, every time, twice daily (infant 0. 5mL, children 1mL).
Last Update：2022-01-01 11:09:59
N-Acetyl-L-Cysteine - Differential diagnosis
Authoritative Data Verified Data
- take about 0.lg of this product, add 2ml of 10% sodium hydroxide solution to dissolve, add 1ml of lead acetate solution, heat and boil, the solution turns yellow-brown, and then produces black precipitate.
- take about 10mg of this product, add 1ml of sodium hydroxide solution to dissolve, add several drops of sodium nitrosoferricyanide solution, shake well, then show deep red color; After placing it, it gradually shows yellow color, with red ring in upper layer, after shaking, it turned red again.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 7).
Last Update：2022-01-01 11:29:12
N-Acetyl-L-Cysteine - Safety
Open Data Verified Data
There was a special odor, causing Nausea and Vomit. Has a stimulating effect on the respiratory tract, can cause bronchospasm, in the solution to join the isoproterenol can be countered; Instilled with sputum suction. Not with metal, especially iron, copper and rubber and oxidant contact; Bronchial asthma patients with caution; Not with penicillin, cephalosporin and tetracycline, etc., because can reduce the antibacterial effect of antibiotics. Suitable for sealing and storage in cool and dark places.
Last Update：2022-01-01 11:09:59
N-Acetyl-L-Cysteine - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, add water to dissolve 20ml, and then determine it according to law (General rule 0631). The pH value should be 1.5~2.5.
clarity of the solution
take this product l.Og, add water 10ml to dissolve, check according to law (General rule 0902 first law), the solution should be clarified.
loss on drying
take this product, with phosphorus pentoxide as desiccant, in 701 vacuum drying for 3 hours, loss of weight shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of burning residual Tong shall be inspected according to law (General rule 0821, Law 2), and the content of heavy metals shall not exceed 10 parts per million.
pyrogen
take this product, add sodium chloride injection to dissolve, adjust the pH value to 7.0 with lmol/L sodium hydroxide solution, dilute with sodium chloride injection to make a solution containing 20mg of acetylcysteine per lml, according to the law inspection (General rule 1142), the dose of rabbit body weight per lkg injection of 10ml, should comply with the provisions. (For injection)
Last Update：2022-01-01 11:29:13
N-Acetyl-L-Cysteine - Content determination
Authoritative Data Verified Data
take about 0.3g of this product, weigh it accurately, add 30ml of water to dissolve it, and then use Iodine titration solution (0.05mol/L) at 20~25°C. The solution was titrated rapidly to a microscopic yellow color and did not fade within 30 seconds. Each lm l Iodine titration solution (0.05mol/L) corresponds to 16.32mg of C5H9N03S.
Last Update：2022-01-01 11:29:14
N-Acetyl-L-Cysteine - Category
Authoritative Data Verified Data
expectorant.
Last Update：2022-01-01 11:29:14
N-Acetyl-L-Cysteine - Storage
Authoritative Data Verified Data
sealed, stored in the cool dark.
Last Update：2022-01-01 11:29:14
N-Acetyl-L-Cysteine - Acetylcysteine
Authoritative Data Verified Data
This product contains acetylcysteine (CsH9NQS) should be labeled 90.0% ~ 110.0%.
trait
This product is soluble fine particles; Gas fragrance.
identification
- take an appropriate amount of this product (about equivalent to acetylcysteine 0.2g), add water to dissolve 20ml, adjust the pH value to 6.5 with 1 mol/L sodium hydroxide solution, and dilute to 40ml with water as the test solution; another 0.2g of acetylcysteine control substance was taken and prepared by the same method as the control substance solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 5fil, respectively point on the same silica gel G thin | Layer plate, with n-butanol-glacial acetic acid-water (4 : 1 : 5) the upper layer liquid mixed and equilibrated for 10 minutes is the developing agent. After spreading, it is taken out, dried under hot air flow, and then colored in iodine vapor, the position and color of the main spot displayed by the test solution should be the same as that of the reference solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution. The above (1), (2) two items can be done one.
examination
- acidity take this product, add water to dissolve and dilute to make 10% of the solution, according to the law (General 0631),p H value should be 2.0~3.0.
- weight loss on drying: take this product at 70T: dry for 4 hours, and the weight loss shall not exceed 2.0% (General rule 0831).
- Related substances take an appropriate amount of fine powder of this product (about 25mg of acetylcysteine), weigh it accurately, put it in a 25ml measuring flask, add mobile phase to dissolve and dilute to the scale, shake well, filter, the continuous filtrate was taken as the test solution; 1ml was accurately measured, placed in a 100ml measuring flask, diluted to the scale with the mobile phase, and shaken, as a control solution.
- According to high performance liquid chromatography (General 0512), silica gel bonded with a Eighteen alkyl silane was used as a filler; Ammonium sulfate buffer (2.25g of ammonium sulfate, sodium heptane sulfonate 1. 82G, diluted to ML with water, adjusted to pH 1.4 with 7mol/L hydrochloric acid solution)-methanol (90: 10) as mobile phase; Detection wavelength was 205nm. The number of theoretical plates is not less than 1000 based on the acetyl cysteine peak. The control solution and the test solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the peak area of a single impurity shall not be greater than the main peak area of the control solution (1. 0), the sum of each impurity peak area shall not be greater than 1 of the main peak area of the control solution. 5 times (1. 5).
- other than the particle size, should comply with the relevant provisions under The granule (General Principles 0104).
containing the most measured
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; 0. 05mol/L two potassium hydrogen phosphate solution (with phosphoric acid to adjust the pH value to 3.0) as the mobile phase; The detection wavelength was 214mn. The number of theoretical plates is not less than 1000 based on the acetyl cysteine peak.
- determine 10 bags of this product, transfer the whole content to a 500ml measuring flask, add an appropriate amount of sodium metabisulfite solution (1-2000), shake to dissolve and dilute to the scale, shake well, take 25ml and place lOOmKO.lg specification) or 200ml(0. 2G specification) in the measuring flask, dilute to the scale with sodium metabisulfite solution (1-2000), shake well, filter, take the continued filtrate as the test solution, and inject 20fJ into the human liquid chromatograph with precision, record the chromatogram; Take about 50mg of acetylcysteine reference substance, weigh it accurately, put it in a 100ml measuring flask, add sodium metabisulfite solution (1-2000) to dissolve and dilute to the scale, shake well, and use it as the reference solution. According to the external standard method to calculate the peak area, that is.
category
homocysteine.
specification
(1)0. lg (2)0. 2g
storage
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 11:29:15
N-Acetyl-L-Cysteine - Acetylcysteine for spray
Authoritative Data Verified Data
This product is calculated according to the average loading, and the content of acetyl cysteine (C5HsN03S) should be 95.0%-105.0% of the labeled amount.
trait
This product is white or off-white crystalline powder.
identification
-
take this product according to the Identification Test (2) under the item of acetylcysteine, and show the same reaction.
- take an appropriate amount of the contents of this product (about equivalent to acetylcysteine 0.2G), add water 20tnl to dissolve, adjust p H value to 6 with lm o l/L sodium hydroxide solution. 5, and diluted with water to 40ml, as a test solution; Another acetylcysteine control 0.2G, prepared by the same method as the control solution. According to the thin layer chromatography (General 0502) test, Draw 5m each of the above two solutions, respectively point on the same silica gel G thin layer. On the plate, the upper layer of n-butanol-glacial acetic acid-water (4 : 1 : 5) mixed and equilibrated for 10 minutes is used as the spreading agent, and after spreading, it is taken out and dried under hot air, in the iodine vapor, the position and color of the main spot of the test solution should be the same as the main spot of the reference solution.
examination
- the acidity, clarity of the solution and loss on drying shall be checked according to the method under the item of acetylcysteine, and shall be in accordance with the regulations.
- the difference in loading should be checked according to the method under the item of sterile powder for injection (General rule 0102), and the regulations should be met.
Content determination
The contents under the item of loading amount difference were collected, mixed uniformly, and measured by the method of acetylcysteine.
category
homocysteine.
specification
(1)0. 5g (2)lg
storage
sealed and kept in cool and dark place.
Last Update：2022-01-01 11:29:16
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