Name | 1-Ethylpiperidine |
Synonyms | NSC 2090 N-Ethylpiperidin 1-Ethylpiperidin N-Ethylpiperidine 1-ethvlpiperidine N-Aethylpiperidin 1-Ethylpiperidine 1-Ethylpiperidene 1-ethyl-piperidin 1-ethylpiperidinium Ethylpiperidylamnie 1-ETHYLPIPERIDINE FOR SYNTHESIS 1-Ethylpiperidine (N-Ethylpiperidin) |
CAS | 766-09-6 |
EINECS | 212-161-6 |
InChI | InChI=1/C7H15N/c1-2-8-6-4-3-5-7-8/h2-7H2,1H3/p+1 |
Molecular Formula | C7H15N |
Molar Mass | 113.2 |
Density | 0.824g/mLat 25°C(lit.) |
Melting Point | -20 °C |
Boling Point | 131°C(lit.) |
Flash Point | 66°F |
Water Solubility | 50 G/L |
Solubility | 1-ethylpiperidine salt of benzylpenicillin is considerably less soluble in amyl acetate and acetone. |
Vapor Presure | 12.76hPa at 20℃ |
Appearance | Liquid |
Color | Clear colorless to slightly yellow |
BRN | 102643 |
pKa | 10.45(at 23℃) |
PH | 12.2 (50g/l, H2O, 20℃) |
Storage Condition | Flammables area |
Explosive Limit | 1.9-12.1%(V) |
Refractive Index | n20/D 1.444(lit.) |
Physical and Chemical Properties | Trait liquid. boiling point 128-129 ℃ relative density 0.82373 refractive index 1.44158 melting point -20 ℃ boiling point 131 ℃ (lit.) density 0.824g/mL at 25°C(lit.) refractive index n20/D 1.444(lit.) flash point 66 ° F. storage conditions Flammables area BRN 102643 |
Use | Used as a pharmaceutical Intermediate |
Risk Codes | R11 - Highly Flammable R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | UN 2386 3/PG 2 |
WGK Germany | 1 |
RTECS | TN0250000 |
FLUKA BRAND F CODES | 10-23 |
TSCA | Yes |
HS Code | 29333990 |
Hazard Class | 3 |
Packing Group | II |
LogP | 1.89 at 25℃ |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | use as a pharmaceutical intermediate for the determination of penicillin G. |
production method | piperidine, sodium and pyridine were mixed, and a nitrogen stream was slowly introduced. The mixture was heated to reflux for 10 minutes with stirring and cooled, under the protection of nitrogen atmosphere, the material was transferred to the autoclave, and ethylene was introduced at a pressure of about 1.1 MPA, heated to 100 ° C., the pressure rose to 1.54 MPa, and stirred until the pressure gradually decreased. After cooling to room temperature, excess ethylene was evolved and the reaction was fractionated and the fractions collected at 129-131 °c gave N-ethylpiperidine in 77-83% yield. |
category | flammable liquid |
toxicity grade | poisoning |
Acute toxicity | intravenous-mouse LD50: 56 mg/kg |
stimulation data | eyes-rabbits 50 mg/5 min moderate |
flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic NOx smoke from combustion |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
extinguishing agent | dry powder, dry sand, foam, carbon dioxide |