N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Allo-Isoleucine
FMOC-D-ALLO-ILE-OH
CAS: 118904-37-3
Molecular Formula: C21H23NO4
N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Allo-Isoleucine - Names and Identifiers
| Name | FMOC-D-ALLO-ILE-OH |
| Synonyms | Fmoc-D-Allo-Lle-Oh FMOC-D-ALLO-ILE-OH Fmoc-D-allo-lle-OH Fmoc-D-Alloisoleucine FMOC-D-ALLO-ISOLEUCINE Fmoc-D-Allo-Isoleucine D-N-FMOC-ALLOISOLEUCINE D-N-Fmoc-Alloisoleucine (2R,3S)-N-Fmoc-2-Amino-3-Methylpentanoic Acid (2R,3S)-N-FMOC-2-AMINO-3-METHYLPENTANOIC ACID N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-D-Alloisoleucine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-ALLO-ISOLEUCINE N-Alpha-(9-Fluorenylmethoxycarbonyl)-D-Allo-Isoleucine N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-ALLO-ISOLEUCINE N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Allo-Isoleucine N-Alpha-(9-Fluoroenylmethyloxycarbonyl)-D-Allo-Isoleucine N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-D-ALLO-ISOLEUCINE |
| CAS | 118904-37-3 |
| InChI | InChI=1/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19+/m0/s1 |
N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Allo-Isoleucine - Physico-chemical Properties
| Molecular Formula | C21H23NO4 |
| Molar Mass | 353.41 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Boling Point | 559.8±33.0 °C(Predicted) |
| Flash Point | 292.4°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 2.28E-13mmHg at 25°C |
| Appearance | Solid |
| pKa | 3.92±0.22(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.582 |
| Physical and Chemical Properties | Storage Conditions: Store at RT. |
N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Allo-Isoleucine - Introduction
N-fluorenylmethoxycarbonyl-D-allo-isoleucine, referred to as Fmoc-allo-isoleucine, is an amino acid derivative. Its properties are as follows:
1. Appearance: Fmoc-allo-isoleucine is a white or slightly yellow crystalline powder.
2. Solubility: It has good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane.
Fmoc-allo-isoleucine is used in biochemistry and medicinal chemistry, mainly for the following purposes:
1. Solid phase synthesis: It is usually used as a raw material for solid phase synthesis of polypeptides, and the polypeptide chain is constructed by continuously adding other amino acids.
2. Drug development: Fmoc-allo-isoleucine can be used to synthesize biologically active peptide drugs or drug precursors.
3. Research purposes: It is often used to study protein structure, function and interaction.
The preparation method of Fmoc-allo-isoleucine mainly includes the following steps:
1. First, N-fluorenomethine is reacted with an activating agent (such as dithioethyl carbamate and N,N'-dicyclohexylcarbodiimide) to obtain N-fluorenylmethoxycarbonyl-D-isoleucine.
2. After completion of the reaction, separation and purification are performed to obtain the target product.
Note the following safety information when using Fmoc-isoleucine:
1. may cause irritation to the respiratory system and skin, so appropriate protective measures should be taken during operation, such as wearing respirators and protective gloves.
2. avoid contact with eyes and skin, if there is contact, should immediately rinse with plenty of water.
3. Follow proper laboratory practices, ensure adequate ventilation and follow laboratory safety regulations. If necessary, please refer to the safety data sheet of the relevant chemical.
1. Appearance: Fmoc-allo-isoleucine is a white or slightly yellow crystalline powder.
2. Solubility: It has good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane.
Fmoc-allo-isoleucine is used in biochemistry and medicinal chemistry, mainly for the following purposes:
1. Solid phase synthesis: It is usually used as a raw material for solid phase synthesis of polypeptides, and the polypeptide chain is constructed by continuously adding other amino acids.
2. Drug development: Fmoc-allo-isoleucine can be used to synthesize biologically active peptide drugs or drug precursors.
3. Research purposes: It is often used to study protein structure, function and interaction.
The preparation method of Fmoc-allo-isoleucine mainly includes the following steps:
1. First, N-fluorenomethine is reacted with an activating agent (such as dithioethyl carbamate and N,N'-dicyclohexylcarbodiimide) to obtain N-fluorenylmethoxycarbonyl-D-isoleucine.
2. After completion of the reaction, separation and purification are performed to obtain the target product.
Note the following safety information when using Fmoc-isoleucine:
1. may cause irritation to the respiratory system and skin, so appropriate protective measures should be taken during operation, such as wearing respirators and protective gloves.
2. avoid contact with eyes and skin, if there is contact, should immediately rinse with plenty of water.
3. Follow proper laboratory practices, ensure adequate ventilation and follow laboratory safety regulations. If necessary, please refer to the safety data sheet of the relevant chemical.
Last Update：2024-04-09 21:21:28
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