N-BUTYLBIGUANIDINE
1-butylbiguanide
CAS: 692-13-7
Molecular Formula: C6H15N5
N-BUTYLBIGUANIDINE - Names and Identifiers
| Name | 1-butylbiguanide |
| Synonyms | DBV Buformin Butformin Buformine Butylbiguanide Butyldiguanide 1-butylbiguanide N-BUTYLBIGUANIDINE |
| CAS | 692-13-7 |
| EINECS | 2117264 |
N-BUTYLBIGUANIDINE - Physico-chemical Properties
| Molecular Formula | C6H15N5 |
| Molar Mass | 157.2168 |
| Density | 1.0291 (rough estimate) |
| Boling Point | 271.89°C (rough estimate) |
| Refractive Index | 1.8070 (estimate) |
N-BUTYLBIGUANIDINE - References
| Biological activity | Buformin (1-Butylbiguanide) is an effective AMPK activator and a biguanide hypoglycemic agent with oral activity (antidiabetic agent). Buformin reduces hepatic gluconeogenesis and blood sugar production. Buformin also has anti-cancer activity and can be applied to cancer research, such as cervical cancer, breast cancer, etc. |
| Cell Line: | ErbB-2-overexpressing SKBR3 and BT474 cells ErbB-2-overexpressing SKBR3 and BT474 cells ErbB-2-overexpressing SKBR3 and BT474 cells |
| Concentration: | 0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300μM, 1, 3, or 10mM 0.5 mM; 1 mM; 3 mM 0mM, 0.1mM, 0.3mM, 1mM, or 3mM |
| Incubation Time: | 5 days 48 hours 24 hours |
| Result: | Reduced cell viability in erbB-2-overexpressing breast cells. Increased cells arresting in G0/G1 phase. Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner. Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice. |
| Animal Model: | Female MMTV-erbB-2 transgenic mice |
| Dosage: | 7.6mmol/kg |
| Administration: | Oral administation; 7 days |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral administration-mouse LD50: 300 mg/kg; Abdominal cavity-mouse LD50: 140 mg/kg |
| flammability hazard characteristics | thermal decomposition discharges toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | water, dry powder, carbon dioxide, foam |
Last Update：2024-04-09 20:49:11
