N-Benzyloxycarbonyl-3-(4-fluorophenyl)-L-alanine
Z-p-fluoro-Phe-OH
CAS: 17543-58-7
Molecular Formula: C17H16FNO4
N-Benzyloxycarbonyl-3-(4-fluorophenyl)-L-alanine - Names and Identifiers
N-Benzyloxycarbonyl-3-(4-fluorophenyl)-L-alanine - Physico-chemical Properties
| Molecular Formula | C17H16FNO4 |
| Molar Mass | 317.31 |
| Melting Point | 158-160℃ (ethyl acetate ligroine ) |
| Storage Condition | 2-8°C |
N-Benzyloxycarbonyl-3-(4-fluorophenyl)-L-alanine - Introduction
Nature:
Z-p-fluoro-Phe-OH is a white solid with a faint peculiar odor. Its chemical formula is C17H15FNO3 and its relative molecular mass is 309.3. The compound is stable at room temperature and can be dissolved in common organic solvents, such as dimethyl sulfoxide, dichloromethane, etc.
Use:
Z-p-fluoro-Phe-OH is an important intermediate in the field of organic synthesis. It is often used for protecting groups and removing groups in the synthesis of amino acid peptide chains. By introducing the Fmoc group, the amino group in the amino acid can be protected to prevent undesired side reactions during the reaction. In the process of peptide chain assembly, which requires the gradual synthesis of amino acids or orientation, the Fmoc group has convenient removal, which makes the compound widely used in solid phase synthesis and liquid phase synthesis.
Method:
The preparation method of the Z-p-fluoro-Phe-OH is usually carried out by the method of amino acid synthesis. First, 4-fluorophenylalanine is synthesized by chemical synthesis or enzymatic catalysis, and then an N-benzyloxycarbonyl group is introduced on the carboxyl group.
Safety Information:
Z-p-fluoro-Phe-OH are chemicals and should be used under the guidance of laboratories or professionals. It may cause irritation and damage to the eyes, skin and respiratory tract. During use, care should be taken to avoid direct contact and wear appropriate protective equipment, such as gloves, glasses and lab clothes. In addition, it should be operated in a well-ventilated place to avoid inhalation or ingestion. During storage, it should be kept in a sealed container, away from fire sources and combustibles. In case of any accident or discomfort, seek medical help immediately.
Last Update：2024-04-10 22:29:15
