N-Boc-1-(hydroxyMethyl)cyclobutylaMine

N-Boc-1-(hydroxyMethyl)cyclobutylaMine - Names and Identifiers

Name	tert-Butyl [1-(hydroxymethyl)cyclobutyl]carbamate
Synonyms	1-(Boc-amino)cyclobutylmethanol N-Boc-1-amino-cyclobutyl-methanol N-Boc-1-(hydroxyMethyl)cyclobutylaMine tert-Butyl [1-(hydroxymethyl)cyclobutyl]carbamate Tert-butyl N-[1-(hydroxymethyl)cyclobutyl]carbamate (1-hydroxyMethylcyclobutyl)carbaMic acid tert-butyl ester 2-Methyl-2-propanyl [1-(hydroxymethyl)cyclobutyl]carbamate Carbamic acid, N-[1-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester
CAS	1142211-17-3
InChI	InChI=1S/C10H19NO3/c1-9(2,3)14-8(13)11-10(7-12)5-4-6-10/h12H,4-7H2,1-3H3,(H,11,13)

N-Boc-1-(hydroxyMethyl)cyclobutylaMine - Physico-chemical Properties

Molecular Formula	C10H19NO3
Molar Mass	201.26
Density	1.08±0.1 g/cm3(Predicted)
Boling Point	312.2±11.0 °C(Predicted)
pKa	12.12±0.20(Predicted)
Storage Condition	2-8°C
Sensitive	Irritant
MDL	MFCD09864392

N-Boc-1-(hydroxyMethyl)cyclobutylaMine - Introduction

(1-(hydroxymethyl) cyclobutyl) carbamic acid tert-butyl ester, the English name is tert-butyl (1-hydroxycylomutyl) carbamate, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
(1-(Hydroxymethyl) cyclobutyl) carbamate tert-butyl ester is a colorless liquid with a special odor. It has a low boiling point and melting point, can be dissolved in a variety of organic solvents, such as ethanol and dimethylformamide.

Use:
This compound is a commonly used protecting group and can be used in organic chemical synthesis. It can be used in the synthesis of other organic compounds and is easily removed by corresponding treatment after the end of the reaction.

Method:
tert-Butyl (1-(hydroxymethyl) cyclobutyl) carbamate can be prepared by the following steps:
1. First, hydroxymethyl cyclobutane and trichloroformate are reacted under the catalysis of alkali to generate trichloromethyl (hydroxymethyl) cyclobutyl formate.
2. Next, the resultant was reacted with tert-butanol to obtain the final product, tert-butyl (1-(hydroxymethyl) cyclobutyl) carbamate.

Safety Information:
tert-Butyl (1-(hydroxymethyl) cyclobutyl) carbamate is generally relatively safe under the conditions of correct use and storage. However, it can be irritating to the eyes and skin. Therefore, appropriate personal protective measures should be taken during handling, such as wearing gloves, goggles and protective clothing. In addition, care should be taken to avoid inhalation or ingestion of the compound.

Please note that in specific experiments and applications, appropriate experimental conditions and safe operating procedures should be followed.

Last Update：2024-04-09 21:01:54