N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine
CAS: 218449-63-9
Molecular Formula: C13H17F2NO3
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine - Names and Identifiers
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine - Physico-chemical Properties
| Molecular Formula | C13H17F2NO3 |
| Molar Mass | 273.28 |
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine - Introduction
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is an organic compound having the chemical structural formula N-Boc-C2(OH)-NH-Ph(F)2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White crystalline solid
-Molecular weight: 271.25g/mol
-Melting Point: about 110-112 ° C
-Solubility: It is soluble in most organic solvents (such as ether, dimethylformamide), and insoluble in water.
Use:
- N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is an important organic synthesis intermediate, often used in the preparation of various drugs and chemical substances.
-it can be used for the synthesis of benzene ginseng acid drugs, anticancer drugs and tyrosine kinase inhibitors.
Method:
The preparation of N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is generally carried out by the following steps:
1. The N-protecting group formic acid (N-Boc) is reacted with 2-chloro-3, 4-difluorophenol to give N-Boc-2-(3,4-difluorophenyl)-2-hydroxyacetic acid.
2. N-Boc-2-(3,4-difluorophenyl)-2-hydroxyacetic acid reacts with silver nitrite under acidic conditions to obtain nitrite.
3. Finally, the nitrous acid ester was subjected to hydroxylamine substitution reaction to obtain the final product N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine.
Safety Information:
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is relatively safe under correct operation, but appropriate laboratory safety measures are still needed.
-It may irritate the eyes, skin and respiratory tract, so contact should be avoided.
-Wear protective glasses, gloves and respiratory protection during operation.
-It should be operated in a well-ventilated place to avoid inhaling gas or vapor.
-Avoid contact with strong oxidants and strong acids during handling, storage and transportation.
In summary, N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is an important organic synthetic intermediate, widely used in the fields of medicine and chemistry. However, it is necessary to comply with safe operating procedures during use.
Nature:
-Appearance: White crystalline solid
-Molecular weight: 271.25g/mol
-Melting Point: about 110-112 ° C
-Solubility: It is soluble in most organic solvents (such as ether, dimethylformamide), and insoluble in water.
Use:
- N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is an important organic synthesis intermediate, often used in the preparation of various drugs and chemical substances.
-it can be used for the synthesis of benzene ginseng acid drugs, anticancer drugs and tyrosine kinase inhibitors.
Method:
The preparation of N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is generally carried out by the following steps:
1. The N-protecting group formic acid (N-Boc) is reacted with 2-chloro-3, 4-difluorophenol to give N-Boc-2-(3,4-difluorophenyl)-2-hydroxyacetic acid.
2. N-Boc-2-(3,4-difluorophenyl)-2-hydroxyacetic acid reacts with silver nitrite under acidic conditions to obtain nitrite.
3. Finally, the nitrous acid ester was subjected to hydroxylamine substitution reaction to obtain the final product N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine.
Safety Information:
N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is relatively safe under correct operation, but appropriate laboratory safety measures are still needed.
-It may irritate the eyes, skin and respiratory tract, so contact should be avoided.
-Wear protective glasses, gloves and respiratory protection during operation.
-It should be operated in a well-ventilated place to avoid inhaling gas or vapor.
-Avoid contact with strong oxidants and strong acids during handling, storage and transportation.
In summary, N-Boc-2-(3,4-difluorophenyl)-2-hydroxyethanamine is an important organic synthetic intermediate, widely used in the fields of medicine and chemistry. However, it is necessary to comply with safe operating procedures during use.
Last Update：2024-04-09 21:00:56
