N-Boc-L-beta-proline
(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
CAS: 140148-70-5
Molecular Formula: C10H17NO4
N-Boc-L-beta-proline - Names and Identifiers
N-Boc-L-beta-proline - Physico-chemical Properties
| Molecular Formula | C10H17NO4 |
| Molar Mass | 215.25 |
| Density | 1.201±0.06 g/cm3(Predicted) |
| Melting Point | 140-145°C |
| Boling Point | 337.2±35.0 °C(Predicted) |
| Flash Point | 157.722°C |
| Water Solubility | Soluble in water (slightly). |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to beige powder |
| pKa | 4.47±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.503 |
| MDL | MFCD03094728 |
| Physical and Chemical Properties | Storage Conditions: Store at 0-5 ℃ |
N-Boc-L-beta-proline - Risk and Safety
| Risk Codes | R41 - Risk of serious damage to eyes R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29333990 |
N-Boc-L-beta-proline - Reference Information
| Introduction | (S)-1-BOC-pyrrolidine -3-formic acid, also known as (S)-N-Boc-β-proline, is an amino acid derivative, which can be prepared by one-step reaction of (S)-β-proline and Boc2O. There are reports that it can be used to prepare USP30 inhibitors. |
| Preparation | Suspended (S)-β-proline (152mg,1.32mmol) and Boc2O(350mg,1.58mmol) on deionized H2O(1mL) and acetone (3mL). The mixture was cooled to 0°C and solid Na2CO3(72mg,0.660mmol) was added. After 3 hours, acetone was removed by vacuum and citric acid aqueous solution (20% w/v) was added dropwise until pH4. The mixture was diluted with H2O(15mL) and EtOAc(15mL). The aqueous phase was extracted with EtOAc(2 × 10mL). The combined organic phase was dried with Na2SO4 and concentrated, after which the product was precipitated into a white solid, giving 284mg(99%) of (S)-1-BOC-pyrrolidin-3-formic acid. |
| Application | (S)-1-BOC-pyrrolidine -3-formic acid can be used to prepare inhibitors involving ubiquitin C- terminal hydrolase 30 or ubiquitin-specific peptidase 30(USP30) having the following structure. |
Last Update：2024-04-09 20:52:54
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View History
N-Boc-L-beta-proline
醋酸十三酯
beta-chloroethyl bromide
卢拉西酮
1,4-DIOXACYCLOHEPTADECANE-5,17-DIONE
3-ISOPROPOXY-1-BROMOBENZENE
Pyriclor
123564-53-4
N-OCTADECAMETHYLDIMETHOXYSILANE
四甲基丙二胺
醋酸十三酯
beta-chloroethyl bromide
卢拉西酮
1,4-DIOXACYCLOHEPTADECANE-5,17-DIONE
3-ISOPROPOXY-1-BROMOBENZENE
Pyriclor
123564-53-4
N-OCTADECAMETHYLDIMETHOXYSILANE
四甲基丙二胺