N-Boc-piperidine-3-methanol
N-Boc-piperidine-3-methanol
CAS: 116574-71-1
Molecular Formula: C11H21NO3
N-Boc-piperidine-3-methanol - Names and Identifiers
N-Boc-piperidine-3-methanol - Physico-chemical Properties
| Molecular Formula | C11H21NO3 |
| Molar Mass | 215.29 |
| Density | 1.059±0.06 g/cm3(Predicted) |
| Melting Point | 77-81 °C |
| Boling Point | 308.0±15.0 °C(Predicted) |
| Flash Point | 140.081°C |
| Solubility | Soluble in methanol and dimethylformamide(DMF). |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to Almost white |
| pKa | 14.93±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.479 |
| MDL | MFCD03094733 |
N-Boc-piperidine-3-methanol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
N-Boc-piperidine-3-methanol - Reference Information
| introduction | 1-Boc-3-hydroxymethylpiperidine has a melting point of 77 to 81 degrees, a boiling point of 308.0±15.0 °C at 760 mmHg, a density of 1.1, and a white or gray solid powder under normal temperature and pressure. 1-Boc-3-hydroxymethylpiperidine has good solubility in common organic solvents such as methanol, N,N-dimethylformamide, and dimethyl sulfoxide. It is often used as an intermediate in organic synthesis, |
| Uses | 1-Boc-3-hydroxymethylpiperidine is a common organic synthesis intermediate, which is often used in drug molecules and biologically active molecules In the modification and derivatization reaction. The ester group in this structure can undergo a series of transformations, including reduction to aldehyde groups, hydroxyl groups, or the preparation of amide compounds by amine ester exchange reaction. In addition, the Boc group on the nitrogen atom can be easily removed to obtain the corresponding secondary amine compounds. |
| Synthesis method | For the synthesis of 1-Boc-3-hydroxymethylpiperidine, the conventional synthesis method is from N-Boc-3-piperidine Starting from ethyl acetate, at room temperature, the reduction of lithium tetrahydroaluminum can efficiently reduce the ester group to hydroxyl group to obtain the target product. It is worth noting that the ester group in the carbonate on the nitrogen atom is not affected in this synthetic route. Through consulting the literature, it is found that one or two ester groups can be selectively reduced by controlling the temperature of lithium tetrahydroaluminum, the ester group on the ring can be reduced at room temperature, and the Boc group can be reduced to methyl group under high temperature reflux. |
| storage method | 1-Boc-3-hydroxymethylpiperidine is sealed and stored in a dry storage device at room temperature. Current data show that the compound has stable chemical properties and is not easy to deteriorate under normal temperature and pressure. In addition, try to avoid oxide contact during storage, and there is no report on its special reactivity, and there is no danger. |
Last Update：2024-04-09 21:11:58
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