N-Boc-tris(hydroxymethyl)aminomethane
N-Boc-Tris
CAS: 146651-71-0
Molecular Formula: C9H19NO5
N-Boc-tris(hydroxymethyl)aminomethane - Names and Identifiers
N-Boc-tris(hydroxymethyl)aminomethane - Physico-chemical Properties
| Molecular Formula | C9H19NO5 |
| Molar Mass | 221.25 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Melting Point | 144-146 °C(Solv: tetrahydrofuran (109-99-9)) |
| Boling Point | 430.5±45.0 °C(Predicted) |
| pKa | 10.66±0.46(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | IRRITANT |
| MDL | MFCD14581676 |
N-Boc-tris(hydroxymethyl)aminomethane - Risk and Safety
| Hazard Class | IRRITANT |
N-Boc-tris(hydroxymethyl)aminomethane - Introduction
N-Boc-Tris (N-Boc-Tris) is an organic compound whose chemical formula is C15H30N3O6. It is a white solid.
N-Boc-Tris have many important applications. First, it is widely used as an amino protecting agent in organic synthesis reactions. Its amino protecting group (BOC group) can stably protect the amino group under many reaction conditions and prevent non-specific reaction. Secondly, it can also be used as an alkali buffer and ligand.
There are several methods of preparing N-Boc-Tris. One commonly used method is to obtain N-Boc-Tris by reacting aminotris (hydroxymethyl) methane with N-tert-butoxycarbazide. Alternatively, tris (hydroxymethyl) amine can be reacted with tert-butyric anhydride to give this compound.
Regarding safety information, N-Boc-Tris is a relatively safe compound under prudent operation, but the following points need to be noted. First of all, it is a deliquescent compound and should avoid contact with moisture and humidity. Second, it may release harmful gases when heated or burned. Therefore, it is necessary to operate in a well-ventilated place to avoid inhaling harmful gases. Finally, it may cause irritation to the eyes, skin, and respiratory tract. Direct contact should be avoided and appropriate personal protective equipment should be worn.
Before using the N-Boc-Tris, it is strongly recommended to carefully read and strictly follow the operating instructions in the chemical safety data sheet and other relevant safety operating manuals.
N-Boc-Tris have many important applications. First, it is widely used as an amino protecting agent in organic synthesis reactions. Its amino protecting group (BOC group) can stably protect the amino group under many reaction conditions and prevent non-specific reaction. Secondly, it can also be used as an alkali buffer and ligand.
There are several methods of preparing N-Boc-Tris. One commonly used method is to obtain N-Boc-Tris by reacting aminotris (hydroxymethyl) methane with N-tert-butoxycarbazide. Alternatively, tris (hydroxymethyl) amine can be reacted with tert-butyric anhydride to give this compound.
Regarding safety information, N-Boc-Tris is a relatively safe compound under prudent operation, but the following points need to be noted. First of all, it is a deliquescent compound and should avoid contact with moisture and humidity. Second, it may release harmful gases when heated or burned. Therefore, it is necessary to operate in a well-ventilated place to avoid inhaling harmful gases. Finally, it may cause irritation to the eyes, skin, and respiratory tract. Direct contact should be avoided and appropriate personal protective equipment should be worn.
Before using the N-Boc-Tris, it is strongly recommended to carefully read and strictly follow the operating instructions in the chemical safety data sheet and other relevant safety operating manuals.
Last Update：2024-04-10 22:29:15
