N-CBZ-3-PYRROLIDINONE - Names and Identifiers
N-CBZ-3-PYRROLIDINONE - Physico-chemical Properties
Molecular Formula | C12H13NO3
|
Molar Mass | 219.24 |
Density | 1.1897 g/mL at 25 °C |
Melting Point | 45-47°C |
Boling Point | 370.2±42.0 °C(Predicted) |
Flash Point | >230°F |
Vapor Presure | 1.13E-05mmHg at 25°C |
Appearance | Crystallization |
pKa | -1.84±0.20(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | n20/D 1.5410 |
MDL | MFCD03001711 |
Physical and Chemical Properties | WGK Germany:2 |
N-CBZ-3-PYRROLIDINONE - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | R22 - Harmful if swallowed
R40 - Limited evidence of a carcinogenic effect
|
Safety Description | S23 - Do not breathe vapour.
S24/25 - Avoid contact with skin and eyes.
S36/37 - Wear suitable protective clothing and gloves.
|
WGK Germany | 2 |
HS Code | 29339900 |
N-CBZ-3-PYRROLIDINONE - Introduction
N-Cbz-3, also known as N-protecting group -3-pyrrolidone, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
N-Cbz-3-pyrrolidone is a white to pale yellow solid with a distinctive odor. It has a relatively high melting and boiling point. This compound is a solid at ambient temperature and is soluble in certain organic solvents such as diethyl ether and dimethylformamide.
Use:
N-Cbz-3-pyrrolidone is a commonly used protecting group compound in the field of organic synthesis. It can be used to protect amino acids, peptides and other compounds containing amino groups from being selectively altered in chemical reactions. It can be used for the protection of enol, enone and enal in synthetic polypeptide and drug research.
Preparation Method:
The preparation of N-Cbz-3-pyrrolidone is generally obtained by reacting 3-pyrrolidone with the chloride of the N-tert-butoxyka protecting group (Cbz). The reaction is generally carried out under anhydrous conditions, usually in an organic solvent.
Safety Information:
N-Cbz-3-pyrrolidone is generally relatively safe under normal use conditions, but some safety measures still need to be paid attention. It can be irritating to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as lab gloves, safety glasses and masks during operation. In addition, avoid prolonged contact with the compound, prevent inhalation of its dust or vapor, and avoid contact with fire sources. Appropriate ventilation and fire prevention measures should be taken during handling and storage. Local regulations should be followed when disposing of waste. It is recommended to refer to the relevant Safety Data Sheet (MSDS) for more detailed safety information.
Last Update:2024-04-09 20:52:54