N-Carbobenzoxy-DL-norleucine
Z-dl-norleucine
CAS: 15027-13-1
Molecular Formula: C14H19NO4
N-Carbobenzoxy-DL-norleucine - Names and Identifiers
| Name | Z-dl-norleucine |
| Synonyms | Z-DL-Nle-OH Z-DL-NLE-OH Z-DL-AHX(2)-OH Z-DL-ACPO(2)-OH Z-dl-norleucine Z-DL-NORLEUCINE CAZ-DL-Norleucine Cbz-DL-norleucine Carbobenzoxynorleucine Z-DL-2-AMINOHEXANOIC ACID N-Carbobenzoxy-DL-norleucine N-CARBOBENZOXY-DL-NORLEUCINE N-[(benzyloxy)carbonyl]norleucine |
| CAS | 15027-13-1 |
| InChI | InChI=1/C14H19NO4/c1-2-3-9-12(13(16)17)15-14(18)19-10-11-7-5-4-6-8-11/h4-8,12H,2-3,9-10H2,1H3,(H,15,18)(H,16,17) |
N-Carbobenzoxy-DL-norleucine - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
| Density | 1.160±0.06 g/cm3(Predicted) |
| Melting Point | 105 °C |
| Boling Point | 449.2±38.0 °C(Predicted) |
| Flash Point | 225.5°C |
| Vapor Presure | 7.43E-09mmHg at 25°C |
| pKa | 4.00±0.21(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.528 |
| MDL | MFCD00037271 |
N-Carbobenzoxy-DL-norleucine - Risk and Safety
| WGK Germany | 3 |
N-Carbobenzoxy-DL-norleucine - Introduction
Z-dl-norleucine is a compound that contains an N-benzyl group and an oxycarbonyl group in its structure. Its properties are as follows:
1. Appearance: usually white crystalline or powdery solid.
2. Thermal stability: It has good thermal stability and can maintain chemical stability within a certain temperature range.
3. Solubility: can be dissolved in water and some organic solvents.
4. Use: Z-dl-norleucine commonly used in the field of biomedicine, as a synthetic peptide drug intermediates. It can be used to synthesize biologically active polypeptides, proteins or antibiotics.
5. Preparation method: The preparation method of Z-dl-norleucine can be achieved by deprotection reaction. The common preparation method is to use p-trimethylsilylethyl methyl chloroiodinone (TBTU) as an activator, to undergo a condensation reaction with norleucine and benzochloroformic acid, and then undergo a treatment of removing the protecting group, finally, the target product is obtained.
6. Safety Information: Z-dl-norleucine has not been studied in detail for safety and toxicity. Wear appropriate personal protective equipment during operation or contact to avoid contact with skin and inhalation of its dust. If exposed or inhaled, immediately wash or breathe fresh air and seek medical attention.
1. Appearance: usually white crystalline or powdery solid.
2. Thermal stability: It has good thermal stability and can maintain chemical stability within a certain temperature range.
3. Solubility: can be dissolved in water and some organic solvents.
4. Use: Z-dl-norleucine commonly used in the field of biomedicine, as a synthetic peptide drug intermediates. It can be used to synthesize biologically active polypeptides, proteins or antibiotics.
5. Preparation method: The preparation method of Z-dl-norleucine can be achieved by deprotection reaction. The common preparation method is to use p-trimethylsilylethyl methyl chloroiodinone (TBTU) as an activator, to undergo a condensation reaction with norleucine and benzochloroformic acid, and then undergo a treatment of removing the protecting group, finally, the target product is obtained.
6. Safety Information: Z-dl-norleucine has not been studied in detail for safety and toxicity. Wear appropriate personal protective equipment during operation or contact to avoid contact with skin and inhalation of its dust. If exposed or inhaled, immediately wash or breathe fresh air and seek medical attention.
Last Update：2024-04-09 02:00:42
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