N-Cyclopropyl
Cyromazine
CAS: 66215-27-8
Molecular Formula: C6H10N6
N-Cyclopropyl - Names and Identifiers
| Name | Cyromazine |
| Synonyms | neoprex trigard cga72662 larvadex ai3-52713 oms-2014 Cyromazine N-Cyclopropyl Cyromazine (200 mg) Vetrazin【pesticide】 cyclopropylmelamine diamino-6-(cyclopropylamino)-s-triazine 5-triazine-2,4,6-triamine,n-cyclopropyl-3 2-cyclopropylamino-4,6-diamino-s-triazine cyclopropyl-1,3,5-triazine-2,4,6-triamine n-cyclopropyl-1,3,5-triazine-2,4,6-triamine Cyromazine, 2-Cyclopropylamino-4,6-diamino-s-triazine |
| CAS | 66215-27-8 |
| EINECS | 266-257-8 |
| InChI | InChI=1/C6H10N6/c7-4-10-5(8)12-6(11-4)9-3-1-2-3/h3H,1-2H2,(H5,7,8,9,10,11,12) |
| InChIKey | LVQDKIWDGQRHTE-UHFFFAOYSA-N |
N-Cyclopropyl - Physico-chemical Properties
| Molecular Formula | C6H10N6 |
| Molar Mass | 166.18 |
| Density | 1.3196 (rough estimate) |
| Melting Point | 223-227 °C (lit.) |
| Boling Point | 284.39°C (rough estimate) |
| Flash Point | 100°C |
| Water Solubility | 13 g l-1 (pH 7.1,25 °C) |
| Solubility | Soluble in methanol, and water (1.1 mg/ml) |
| Vapor Presure | 4.5 x l0-7 Pa (25 °C) |
| Appearance | White crystal |
| Color | White to Off-White |
| Merck | 14,2775 |
| BRN | 882879 |
| pKa | 5.2 (base) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.8300 (estimate) |
| MDL | MFCD00078650 |
| Physical and Chemical Properties | Melting Point: 220-222°C |
| Use | It is mainly used to control the insect pests of the leaf fly, and has good control effect on the fly, and can also be used to control flies |
N-Cyclopropyl - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN3077 (solid) |
| WGK Germany | 2 |
| RTECS | XZ1056500 |
| HS Code | 29336990 |
| Toxicity | LC50 (96-hour) for rainbow trout and carp >100 mg/L and bluegill sunfish >90 mg/L (Hartley and Kidd, 1987); acute oral LD50 for rats 3,387 mg/kg (Hartley and Kidd, 1987) |
N-Cyclopropyl - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Cyclopropylamine Cyanuric chloride |
N-Cyclopropyl - Introduction
Cyromazine is a non-organophosphorus insect growth regulator.
Last Update：2022-10-16 17:27:47
N-Cyclopropyl - Reference Information
| LogP | -0.061 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | cyromazine, also known as maggoidene, is a new type of insect growth regulator, the killing effect on the larvae of Diptera insects is particularly good at inhibiting and killing several common fly larvae (maggots) that reproduce in feces. The difference between it and the general Musca is that it kills larvae-maggots, while the general Musca only kills flies and is more toxic. |
| pharmacological action | This product belongs to 1,3, 5-triazine insect growth regulator, which has special activity to Diptera larvae, strong internal absorption and conduction. Diptera larvae and pupae are induced to undergo morphological aberrations, incomplete eclosion or inhibition of adults. |
| preparation | cyanuric chloride reacts with ammonia under stirring at room temperature, the BIS-amino substituent 3 (6-chloro-2, 4-diamino-1, 3, 5-triazine) was filtered and reacted with cyclopropylamine at 110 to obtain cyromazine, the operation is simple, but the last step is to add an excess of high-priced cyclopropylamine, and the recovery is required in the post-treatment, which makes the process more difficult. The total yield of the two-step reaction was 69. 7%. |
| toxicity | Acute oral LD50 of the original drug in rats was 3387mg/kg; Acute percutaneous LD50>3100mg/kg; acute inhalation LC50>2720mg/m3(4H). It has slight irritation to rabbit skin and no irritation to eyes. 75% wettable powder on rats with acute oral LD50>5000mg/kg; Acute percutaneous LD50>2000mg/kg; Acute inhalation LC50>2120mg/m3; Moderate irritation to rabbit skin, slightly irritating to the eyes. Rainbow trout and carp LC50>100mg/L; Blue gill and catfish LC50>90mg/L. The actual non-toxic to birds, short-tailed quail LD50 1785mg/kg, wild duck LD50>2510mg/kg. No effect of bee exposure dose of 5g/only. |
| Application | insect growth regulator for controlling leaf fly. Diptera larvae and pupae in the development process of morphological distortion, eclosion of adults inhibited or incomplete, this is due to the interference caused by molting and pupation. There was no lethal effect on adult worms, either orally or topically, but the hatching rate of eggs decreased after oral ingestion. In the plant body has the role of absorption, applied to the leaves have a strong conduction, applied to the soil by the root absorption, to the top conduction. Apply to beans, carrots, celery, melon, lettuce, onion, pea, green pepper, potato, tomato with 12~30g/100L medicament treatment, or 75~225g/hm2. The high dose was significantly longer than the low dose. The soil application dose was 200 ~ 1000g/hm2, and the effect of high dose was 8 weeks. It is mainly used to control the insect pests of the leaf fly, which has good control effect on the leaf fly, and can also be used to control flies. It is a kind of insecticide with high efficiency and low toxicity. |
| production method | 2-cyclopropylamino-4 is prepared from cyanuric chloride and cyclopropylamine, 2-cyclopropylamino-4-chloro-6-amino-triazobenzene was prepared by the reaction of 6-dichloro-s-triazobenzene with ammonia. Finally, cyromazine was prepared by the reaction with ammonia. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Raw Materials for N-Cyclopropyl