N-Desmethyltamoxifen

Name	N-Desmethyltamoxifen
Synonyms	N-Desmethyltamoxifen Tamoxifen EP Impurity F N-DESMETHYL TAMOXIFEN HCL N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N-methylethanamine (Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
CAS	31750-48-8

biological activity	N-Desmethyltamoxifen is the main metabolite of Tamoxifen in human body. N-Desmethyltamoxifen, the weaker antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
Cell Line:	MCF 7 human mammary carcinoma cells
Concentration:	1.5, 2.5, 5, 7.5, 10 μM
Incubation Time:	114 hours
Result:	Inhibits growth of MCF 7 human mammary carcinoma cells

Last Update：2024-04-09 21:04:16