N-Methoxy-N-methylacetamide
N-Methoxy-N-methylacetamide
CAS: 78191-00-1
Molecular Formula: C4H9NO2
N-Methoxy-N-methylacetamide - Names and Identifiers
| Name | N-Methoxy-N-methylacetamide |
| Synonyms | N-Methoxy-N-methyL N-METHOXY-N-METHLACETAMIDE N-Methoxy-N-methylacetamid N-Methyl-N-methoxyacetamide N-Methoxy-N-methylacetamide N-METHOXY-N-METHYLACETAMIDE Acetamide, N-methoxy-N-methyl- AcetaMide, N-Methoxy-N-Methyl- N-ACETYL-N,O-DIMETHYLHYDROXYLAMINE |
| CAS | 78191-00-1 |
| EINECS | 628-920-3 |
| InChI | InChI=1/C4H9NO2/c1-4(6)5(2)7-3/h1-3H3 |
N-Methoxy-N-methylacetamide - Physico-chemical Properties
| Molecular Formula | C4H9NO2 |
| Molar Mass | 103.12 |
| Density | 0.97 g/mL at 25 °C (lit.) |
| Boling Point | 152 °C (lit.) |
| Flash Point | 121°F |
| Water Solubility | Soluble |
| Vapor Presure | 52.7mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | n20/D 1.426(lit.) |
N-Methoxy-N-methylacetamide - Risk and Safety
| Risk Codes | 10 - Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29280000 |
| Hazard Class | 3 |
| Packing Group | III |
N-Methoxy-N-methylacetamide - Reference Information
| Application | N-methoxy-N-methylacetamide is a common weinreb amide Synthon, weinreb amide is N-methoxy-N-methyl amide. |
| preparation | to N,O-dimethylhydroxylamine hydrochloride (8.05G, 82.8 mmol, 1.0 equiv.) to a solution in dichloromethane (200 ml) was added triethylamine (23.1 ML, 16.8G, 166 mmol, 2.0 equiv.). Acetyl chloride (11a;5.91mL,6.50g,82.8mmol) was added dropwise at 0 °c. The resulting mixture was stirred at ambient temperature for 17 h and quenched with saturated sodium bicarbonate (130 ml). The aqueous layer was separated and extracted with CH2Cl2(3 x 50ml). The combined organic extracts were washed with hydrochloric acid solution (1m;50ml) and brine (50ml) and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by distillation (B. p. 65 °c, 50mbar) to give the title compound. |
Last Update：2024-04-10 22:29:15
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CAS: 78191-00-1
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