N-Methyl-N-nitrosourea
Methylnitrosourea
CAS: 684-93-5
Molecular Formula: C2H5N3O2
N-Methyl-N-nitrosourea - Names and Identifiers
| Name | Methylnitrosourea |
| Synonyms | NMH NMU MNU sri 859 ski 24464 Methylnitrosourea Nitrosomethylurea 1-(nitrosomethyl)urea 1-Methyl-1-Nitrosourea 1-nitroso-1-methylurea N-Methyl-N-nitrosourea N-Nitroso-N-Methylurea N-methyl-N-nitroso-Urea N-nitroso-N-methylcarbamide N-Nitrosomethylurea - Carc. n-methyl-n-nitroso-carbamide |
| CAS | 684-93-5 |
| EINECS | 211-678-4 |
| InChI | InChI=1/C2H5N3O2/c3-2(6)4-1-5-7/h1H2,(H3,3,4,6) |
N-Methyl-N-nitrosourea - Physico-chemical Properties
| Molecular Formula | C2H5N3O2 |
| Molar Mass | 103.08 |
| Density | 1.58g/cm3 |
| Melting Point | 124 |
| Boling Point | 188.3°C at 760 mmHg |
| Flash Point | 67.7°C |
| Water Solubility | Soluble. <0.1 g/100 mL at 18 C |
| Vapor Presure | 0.605mmHg at 25°C |
| Refractive Index | 1.574 |
| Physical and Chemical Properties | Chemical properties yellow flake crystal (ethanol), melting point 124 ℃ (decomposition), room temperature storage may decompose and cause explosion. |
| Use | Use an intermediate of dexamethasone acetate. The laboratory is used for the production of diazomethane. |
N-Methyl-N-nitrosourea - Risk and Safety
| Hazard Symbols | F - Flammable T - Toxic  |
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R61 - May cause harm to the unborn child R11 - Highly Flammable R25 - Toxic if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1325 |
N-Methyl-N-nitrosourea - Upstream Downstream Industry
N-Methyl-N-nitrosourea - Nature
| storage conditions | 2-8°C |
| acidity coefficient (pKa) | 12.36±0.50(Predicted) |
| water solubility | 14.56g/L(temperature not stated) |
| stability | Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong acids. |
| (IARC) Carcinogen Classification | 2A (Vol. 17, Sup 7) 1987 |
| NIST chemical information | Urea, 1-methyl-1-nitroso-(684-93-5) |
| EPA chemical information | N-Nitroso-N-methylurea (684-93-5) |
Last Update：2024-04-10 22:29:15
N-Methyl-N-nitrosourea - Security information
| WGK Germany | - |
| RTECS number | YT7875000 |
| HazardClass | 6.1( B ) |
| PackingGroup | III |
| customs code | 29241990 |
| toxic substance data | 684-93-5(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 110mg/kg |
Last Update：2024-04-10 22:29:15
N-Methyl-N-nitrosourea - Uses and synthesis methods
biological activity
N-Nitroso-N-methylurea (NMU;MNU;NMH) is an effective carcinogen, mutagen and teratogen. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea target a variety of animal organs to cause various cancers and/or degenerative diseases. N-Nitroso-N-methylurea is also a precursor substance in diazomethane synthesis.
in vitro study
N-Nitroso-N-methylurea (NMU; 5 μM) treatment increases the cellular NF-κ B activity in human malignant keratinocytes. N-Nitroso-N-methylurea also increases the amount of I-κBα phosphorylation.
in vivo studies
N-Nitroso-N-methylurea (NMU) gives intravenously to rats at age 50 days induced mammary carcinomas in 89% of BUF/N, 73% of Sprague-Dawley, and 89% of F344 females. Latent periods are, respectively, 77, 86, and 94 days. Doubling times of NMU-induced primary and transplanted carcinomas are similar to 7 days. Cachexia ensues at the 5th week from the onset of the first tumor. When the tumor is larger than 15 g, hypercalcemia is usually observed.
production method
It is prepared by boiling methylamine, concentrated hydrochloric acid, water and urea, and reacting with sodium hydroxide after cooling.
Last Update：2024-04-09 19:04:55
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Raw Materials for N-Methyl-N-nitrosourea
Downstream Products for N-Methyl-N-nitrosourea
3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate
9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
3-METHYL URIDINE
1,1-DIETHYLUREA
1-PHENYLSEMICARBAZIDE
9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
3-METHYL URIDINE
1,1-DIETHYLUREA
1-PHENYLSEMICARBAZIDE