N-Methylpiperidine
N-Methylpiperidine
CAS: 626-67-5
Molecular Formula: C6H13N
N-Methylpiperidine - Names and Identifiers
| Name | N-Methylpiperidine |
| Synonyms | lk20 NMPPR N-MEPIP 1-METHYLPIPERIDINE 1-methyl-piperidin N-Methylpiperidine N-METHYLPIPERIDINE N-methylpepiridine 1-Methylpiperidine 1-methylpiperidinium Piperidine,1-methyl- |
| CAS | 626-67-5 |
| EINECS | 210-959-9 |
| InChI | InChI=1/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3/p+1 |
N-Methylpiperidine - Physico-chemical Properties
| Molecular Formula | C6H13N |
| Molar Mass | 99.17 |
| Density | 0.816 g/mL at 25 °C (lit.) |
| Melting Point | -50 °C |
| Boling Point | 106-107 °C (lit.) |
| Flash Point | 38°F |
| Water Solubility | miscible |
| Vapor Presure | 35.7hPa at 20℃ |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 1073 |
| pKa | 10.08(at 25℃) |
| PH | 12 (100g/l, H2O, 20℃) |
| Storage Condition | −20°C |
| Explosive Limit | 1.1-9.9%(V) |
| Refractive Index | n20/D 1.438 |
| Physical and Chemical Properties | Characteristics of colorless liquid, irritating odor. boiling point 107 ℃ relative density 0.8159g/cm3 refractive index 1.4355 soluble in water, alcohol and ether. |
| Use | Useful as intermediates in pharmaceuticals and Organic synthesis |
N-Methylpiperidine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns R20/22 - Harmful by inhalation and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R67 - Vapors may cause drowsiness and dizziness R22 - Harmful if swallowed R10 - Flammable R37 - Irritating to the respiratory system |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S9 - Keep container in a well-ventilated place. S33 - Take precautionary measures against static discharges. |
| UN IDs | UN 3286 3/PG 2 |
| WGK Germany | 3 |
| RTECS | TN1225000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29333999 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 intraperitoneal in mouse: 400mg/kg |
N-Methylpiperidine - Nature
Open Data Verified Data
colorless liquid with pungent odor. Class I flammability. Soluble in water, alcohol, ether. Density 0. 815 9g/cm3, boiling point 107 ℃, refractive index 1. 4355(20 ℃).
Last Update：2024-01-02 23:10:35
N-Methylpiperidine - Preparation Method
Open Data Verified Data
with formaldehyde, formic acid as methylation reagent, and six hydrogen pyridine reaction.
Last Update：2022-01-01 10:53:48
N-Methylpiperidine - Use
Open Data Verified Data
Pharmaceutical, pesticide and other industries for organic synthesis intermediates.
Last Update：2022-01-01 10:53:47
N-Methylpiperidine - Safety
Open Data Verified Data
- when it is highly alkaline, the inlet eyes should be flushed with plenty of water immediately.
- 200L galvanized iron drum, 16 0kg net weight, sealed and stored in a cool place. According to the flammable storage.
Last Update：2022-01-01 10:53:48
N-Methylpiperidine - Reference Information
| LogP | 1.15 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | Used as an intermediate in pharmaceutical and organic synthesis 1-methylpiperidine is an intermediate of the plant growth regulator mepiperone. |
| production method | its preparation method is to add piperidine and formaldehyde in the reaction kettle, finally add formic acid, heat, keep the temperature at 90 ℃, react for 6 hours, cool, add hydrochloric acid to the mixture, heat up and evaporate excess formaldehyde and formic acid, cool the residue, add sodium hydroxide, heat up and evaporate 1-methyl piperidine and water mixture, the mixture is dried by solid sodium hydroxide and distilled in a distillation kettle to obtain the product. |
| category | flammable liquid |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-mouse LD50: 400 mg/kg; Subcutaneous-rabbit LDL0: 300 mg/kg |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; toxic nitrogen oxide smoke from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
Last Update：2024-04-09 21:11:58
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Tel: +86-17551318830
Email: r@reformchem.com
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Product Name: Loratadine Impurity 89 Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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Product Name: N-Methylpiperidine Request for quotation
CAS: 626-67-5
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CAS: 626-67-5
Tel: 17505222756
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