N-Phenylpyrimidin-2-amine
N-Phenyl-2-pyrimidinamine
CAS: 57356-49-7
Molecular Formula: C10H9N3
N-Phenylpyrimidin-2-amine - Names and Identifiers
| Name | N-Phenyl-2-pyrimidinamine |
| Synonyms | 2-Anilinopyrimidine 2-Anilinopyrirmidine 2-Phenylaminopyrimidine N-phenylpyriMidin-2-aMine N-Phenylpyrimidin-2-amine 2-(Phenylamino)pyrimidine N-Phenyl-2-pyrimidinamine N-Phenylpyrimidine-2-amine 2-Pyrimidinamine, N-phenyl- N-phenylpyrimidin-2-amine analogue |
| CAS | 57356-49-7 |
| InChI | InChI=1/C10H9N3/c1-2-5-9(6-3-1)13-10-11-7-4-8-12-10/h1-8H,(H,11,12,13) |
| InChIKey | XGXNTJHZPBRBHJ-UHFFFAOYSA-N |
N-Phenylpyrimidin-2-amine - Physico-chemical Properties
| Molecular Formula | C10H9N3 |
| Molar Mass | 171.2 |
| Density | 1.206 |
| Melting Point | 115-116℃ |
| Boling Point | 331.6±25.0 °C(Predicted) |
| Flash Point | 154.319°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 3.00±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.651 |
N-Phenylpyrimidin-2-amine - Risk and Safety
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
N-Phenylpyrimidin-2-amine - Introduction
N-Phenyl-2-pyrimidinamine(N-Phenyl-2-pyrimidinamine) is an organic compound whose chemical formula is C11H9N3. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: N-Phenyl-2-pyrimidinamine is white to light yellow crystal.
-Solubility: Soluble in most organic solvents, such as chloroform, methanol and ether.
-Melting point: about 120-125°C.
-Stability: Stable at room temperature, but avoid moisture or contact with strong oxidants.
Use:
- N-Phenyl-2-pyrimidinamine can be used to synthesize other organic compounds, such as fluorescent dyes, pesticide intermediates, etc.
-It can also be used as a pharmaceutical research intermediate for the synthesis of anti-leukemia drugs.
Preparation Method:
N-Phenyl-2-pyrimidinamine preparation methods are usually based on the corresponding aminopyrimidine compounds:
1. Benzanilide is first obtained by reacting aniline with a chloroformate (e. g. benzyl chloroformate).
2. Condensation reaction of benzanilide and aminopyrimidine under alkaline conditions to give N-Phenyl-2-pyrimidinamine.
Safety Information:
-The toxicity of N-Phenyl-2-pyrimidinamine has not been fully studied. Please follow laboratory safety practices and prevent contact with skin, eyes and respiratory system.
-Avoid inhaling its dust or mist, and maintain adequate ventilation during operation.
-If skin contact occurs, rinse immediately with plenty of water and seek medical help.
-Avoid eating or drinking, and do not smoke or engage in any dangerous activity.
-During storage, keep it away from ignition and flammable substances, and store it properly sealed.
Nature:
-Appearance: N-Phenyl-2-pyrimidinamine is white to light yellow crystal.
-Solubility: Soluble in most organic solvents, such as chloroform, methanol and ether.
-Melting point: about 120-125°C.
-Stability: Stable at room temperature, but avoid moisture or contact with strong oxidants.
Use:
- N-Phenyl-2-pyrimidinamine can be used to synthesize other organic compounds, such as fluorescent dyes, pesticide intermediates, etc.
-It can also be used as a pharmaceutical research intermediate for the synthesis of anti-leukemia drugs.
Preparation Method:
N-Phenyl-2-pyrimidinamine preparation methods are usually based on the corresponding aminopyrimidine compounds:
1. Benzanilide is first obtained by reacting aniline with a chloroformate (e. g. benzyl chloroformate).
2. Condensation reaction of benzanilide and aminopyrimidine under alkaline conditions to give N-Phenyl-2-pyrimidinamine.
Safety Information:
-The toxicity of N-Phenyl-2-pyrimidinamine has not been fully studied. Please follow laboratory safety practices and prevent contact with skin, eyes and respiratory system.
-Avoid inhaling its dust or mist, and maintain adequate ventilation during operation.
-If skin contact occurs, rinse immediately with plenty of water and seek medical help.
-Avoid eating or drinking, and do not smoke or engage in any dangerous activity.
-During storage, keep it away from ignition and flammable substances, and store it properly sealed.
Last Update：2024-04-09 15:17:58
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CAS: 57356-49-7
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