N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine
fmoc-O-trityl-L-serine
CAS: 111061-56-4
Molecular Formula: C37H31NO5
N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine - Names and Identifiers
| Name | fmoc-O-trityl-L-serine |
| Synonyms | FMoc-Ser(trt) Fmoc-Ser(Trt)-OH FMOC-SER(TRT)-OH FMOC-L-SER(TRT)-OH FMOC-O-TRITYL-L-SERINE fmoc-O-trityl-L-serine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-L-serine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-D-serine N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine FMOC-L-SER(TRT)-OH FMOC-O-TRITYL-L-SERINE FMOC-SERINE(TRT)-OH FMOC-SER(TRT)-OH n-(9-fluorenylMethoxycarbonyl)-o-trityl-l-serine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-TRITYL-L-SERINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TRITYL-L-SERINE N-ALPHA-FMOC-O |
| CAS | 111061-56-4 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C37H31NO5/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m1/s1 |
| InChIKey | UCARTONYOJORBQ-UMSFTDKQSA-N |
N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine - Physico-chemical Properties
| Molecular Formula | C37H31NO5 |
| Molar Mass | 569.65 |
| Density | 1.256±0.06 g/cm3(Predicted) |
| Melting Point | 200-210°C (dec.) |
| Boling Point | 750.4±60.0 °C(Predicted) |
| Specific Rotation(α) | 8 º (c=1%, DMF) |
| Flash Point | 407.627°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to light yellow crystal powder |
| BRN | 5684859 |
| pKa | 3.33±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.639 |
| MDL | MFCD00153364 |
N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29242990 |
N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine - Introduction
Fmoc-O-trityl-L-serine is a commonly used amino acid protecting group with the following properties:
1. appearance: white or white solid.
2. solubility: in some organic solvents (such as dimethyl sulfoxide, dichloromethane, etc.) can be better dissolved.
3. stability: relatively stable under the conditions of common oxidants and enzymes.
Fmoc-O-trityl-L-serine is commonly used in solid-phase synthesis as a protecting group to prevent side reactions of unreacted functional groups with other substances in the reaction solution. In addition, it can also be used as a starting material in the synthesis of biologically active polypeptides or proteins.
The preparation method of this compound is usually to react the Fmoc group with L-serine through a homologous reaction to generate Fmoc-O-trityl-L-serine.
Regarding safety information, the following points should be noted:
1. Fmoc-O-trityl-L-serine may be irritating to eyes, respiratory system and skin, direct contact should be avoided.
2. During operation, appropriate personal protective equipment should be worn, such as lab gloves, safety glasses and protective masks.
3. Observe proper laboratory safety practices when storing and handling the compound.
4. When using the compound for experiments, ensure that the operation is carried out in a well-ventilated environment.
1. appearance: white or white solid.
2. solubility: in some organic solvents (such as dimethyl sulfoxide, dichloromethane, etc.) can be better dissolved.
3. stability: relatively stable under the conditions of common oxidants and enzymes.
Fmoc-O-trityl-L-serine is commonly used in solid-phase synthesis as a protecting group to prevent side reactions of unreacted functional groups with other substances in the reaction solution. In addition, it can also be used as a starting material in the synthesis of biologically active polypeptides or proteins.
The preparation method of this compound is usually to react the Fmoc group with L-serine through a homologous reaction to generate Fmoc-O-trityl-L-serine.
Regarding safety information, the following points should be noted:
1. Fmoc-O-trityl-L-serine may be irritating to eyes, respiratory system and skin, direct contact should be avoided.
2. During operation, appropriate personal protective equipment should be worn, such as lab gloves, safety glasses and protective masks.
3. Observe proper laboratory safety practices when storing and handling the compound.
4. When using the compound for experiments, ensure that the operation is carried out in a well-ventilated environment.
Last Update：2024-04-09 20:52:54
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