N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine
(S)-N-BOC-4-Fluorophenylalanine
CAS: 41153-30-4
Molecular Formula: C14H18FNO4
N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine - Names and Identifiers
| Name | (S)-N-BOC-4-Fluorophenylalanine |
| Synonyms | Boc-Phe(4-F)-OH Boc-L-4-Fluorophe Boc-4-Fluoro-L-Phe-OH Boc-L-4-Fluoro-phe-OH Boc-L-4-Fluorophenylalanine Boc-4-Fluoro-L-phenylalanine (S)-N-BOC-4-Fluorophenylalanine N-Boc-4-fluoro-L-phenylalanineBoc-Phe(4-F)-OH Boc-L-Phe(4-F) -OH Boc-4-Fluoro-L-Phenylalanine N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-4-fluoro- |
| CAS | 41153-30-4 |
| InChI | InChI=1/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1 |
N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine - Physico-chemical Properties
| Molecular Formula | C14H18FNO4 |
| Molar Mass | 283.3 |
| Density | 1.1918 (estimate) |
| Melting Point | 83-86°C |
| Boling Point | 431.2±40.0 °C(Predicted) |
| Specific Rotation(α) | 8 º (c=1,MeOH) |
| Flash Point | 214.6°C |
| Vapor Presure | 3.36E-08mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| BRN | 4323475 |
| pKa | 3.87±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.517 |
| MDL | MFCD00079672 |
| Physical and Chemical Properties | Melting point 80°C specific optical rotation 8 ° (c = 1,MeOH) |
N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Note | Irritant/Keep Cold |
N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine - Introduction
Nature:
(S)-N-BOC-4-Fluorophenylalanine is a white crystalline solid with a specific chemical structure. Its chemical formula is C15H18FNO4 and its molecular weight is 301.31g/mol. It is a photosensitive compound and should avoid prolonged exposure to light. At room temperature, it is stable and soluble in ethanol and dimethylformamide.
Use:
(S)-N-BOC-4-Fluorophenylalanine is a biologically active amino acid derivative. It is commonly used in the fields of pharmaceutical research and organic synthesis. One of its main uses is its application as a chiral inducer in asymmetric synthesis to synthesize organic molecules with specific stereostructures. In addition, it can also be used in the synthesis of drugs and peptide compounds, as biological detection reagents and protein modification reagents.
Preparation Method:
The method for preparing (S)-N-BOC-4-Fluorophenylalanine can be obtained by reacting L-phenylalanine with 4-fluorobenzoic anhydride for esterification. In the reaction, the amino group is protected using a BOC protecting group (tert-butoxycarbonyl). Finally, the pure product can be obtained by crystallization purification.
Safety Information:
(S)-N-BOC-4-Fluorophenylalanine specific safety information requires compliance with safe practices for chemicals. It is a chemical that is irritating to the skin and eyes, so it is necessary to wear appropriate protective gloves and goggles during operation. In addition, it should be stored in a dry, cool place and avoid contact with strong oxidants. If exposed or inhaled, seek medical help immediately.
Last Update：2024-04-09 20:52:54
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Product Name: Boc-L-4-Fluorophe Visit Supplier Webpage Request for quotationCAS: 41153-30-4
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Mobile: 18021002903
QQ: 3008007409
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