N-benzyl-N-methylprop-2-yn-1-amine
pargyline hydrochloride
CAS: 306-07-0
Molecular Formula: C11H14ClN
N-benzyl-N-methylprop-2-yn-1-amine - Names and Identifiers
| Name | pargyline hydrochloride |
| Synonyms | Parguline HCL pargyline hcl PARGYLINE HYDROCHLORIDE pargyline hydrochloride N-benzyl-N-methylprop-2-yn-1-amine benzylmethylpropynylaminehydrochloride n-benzyl-n-methyl-2-propynylaminhydrochloride n-methyl-n-2-propynyl-benzylaminhydrochloride N-METHYL-N-PROPARGYLBENZYLAMINE HYDROCHLORIDE N-Methyl-N-2-propynylbenzylamine hydrochloride N-methyl-N-propargylbenzylamine hydro-chloride n-benzyl-n-methyl-2-propynylaminehydrochloride N-METHYL-N-2-PROPYNYLBENZYLAMINE HYDROCHLORIDE N-METHYL-N-(2-PROPYNY)BENZYLAMINE HYDROCHLORIDE |
| CAS | 306-07-0 |
| EINECS | 206-175-1 |
| InChI | InChI=1/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H |
| InChIKey | BCXCABRDBBWWGY-UHFFFAOYSA-N |
N-benzyl-N-methylprop-2-yn-1-amine - Physico-chemical Properties
| Molecular Formula | C11H14ClN |
| Molar Mass | 195.69 |
| Melting Point | 160-163°C(lit.) |
| Boling Point | 228.4°C at 760 mmHg |
| Flash Point | 83.9°C |
| Vapor Presure | 0.0736mmHg at 25°C |
| Color | Crystals from EtOH/Et2O |
| Merck | 13,7110 |
| BRN | 3699487 |
| Storage Condition | -20°C |
| MDL | MFCD00012492 |
| Use | It has obvious antihypertensive effect and monoamine oxidase (MAO-B) selective inhibitor. |
| In vitro study | Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner. Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner. Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells. Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression. Cell Proliferation Assay Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM, 1 mM, 1.5 mM or 2 mM Incubation Time: 24 hours, 48 hours, 72 hours, 96 hours or 120 hours Result: Inhibited the proliferation of prostate cancer cells in a time- and dose-dependent manner. Cell Cycle Analysis Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM, 2 mM Incubation Time: 24 hours, 48 hours Result: The S phase ratio of the cells was decreased, while their G1 phase ratio was increased. Apoptosis Analysis Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM Incubation Time: 24 hours Result: Increased the apoptotic cells. Western Blot Analysis Cell Line: LNCaP-LN3 cells Concentration: 2 mM Incubation Time: 48 hours Result: Induced an increase of cytochrome c and a decrease of caspase-3. |
| In vivo study | Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats. A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain. |
N-benzyl-N-methylprop-2-yn-1-amine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DP6650000 |
| FLUKA BRAND F CODES | 10 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 250 mg/kg 27ZQAG -,401,72 |
N-benzyl-N-methylprop-2-yn-1-amine - Introduction
It stinks. Soluble in water. The aqueous solution is unstable, and the 3.18% solution is an isotonic solution.
Last Update：2022-10-16 17:24:28
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