N-difluoroMenthyl-4-nitropyrazole
N-difluoroMenthyl-4-nitropyrazole
CAS: 956477-64-8
Molecular Formula: C10H12O4
N-difluoroMenthyl-4-nitropyrazole - Names and Identifiers
N-difluoroMenthyl-4-nitropyrazole - Physico-chemical Properties
| Molecular Formula | C10H12O4 |
| Molar Mass | 196.19988 |
| Density | 1.71±0.1 g/cm3(Predicted) |
| Boling Point | 87-90℃ (20 Torr) |
| pKa | -5.19±0.19(Predicted) |
| Storage Condition | 2-8°C |
| Use | Application 1-difluoromethyl-4-nitropyrazole is an organic intermediate, which can be prepared in one step by 4-nitro-1H-pyrazole and sodium 2-chloro-2, 2-difluoroacetate, or obtained by nitration of 1-difluoromethylpyrazole. |
N-difluoroMenthyl-4-nitropyrazole - Upstream Downstream Industry
| Downstream Products | 1-(difluoromethyl)-1h-pyrazol-4-amine |
N-difluoroMenthyl-4-nitropyrazole - Preparation
The mixture of 4-nitro-1H-pyrazole (2g, 17.69 mmol), Cs2CO3 (5.76g, 17.69 mmol) and sodium 2-chloro-2, 2-difluoroacetate (5.39g, 35.4 mmol) in DMF (10 mL) was stirred at 120°C for 2 h under nitrogen. Cool it to rt and dilute it with water (20 mL). The mixture was extracted with EtOAc (70 mL x 3). The combined organic layer was washed with water (40 mL) and brine (50 mL), dried, filtered and concentrated by anhydrous sodium sulfate. The residue was purified by rapid column chromatography on silica gel (elution with petroleum ether: ethyl acetate = 100:1 to 10: 1 gradient) to give 1-difluoromethyl-4-nitropyrazole.
Last Update：2024-04-10 22:29:15
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