N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide

Name	ARP100
Synonyms	ARP100 MMP-2 Inhibitor III N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-
CAS	704888-90-4

Molecular Formula	C17H20N2O5S
Molar Mass	364.42
Solubility	Soluble at 100mM in DMSO
Appearance	Solid
Storage Condition	Desiccate at +4°C
In vitro study	ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations.

Usage	ARP 100 is a potent dual inhibitor of MMP-12/MMP-13 targets, MMP-12/MMP-13 targets a family of zinc-dependent endopeptidases known to play a key role in disorders of extracellular matrix (ECM) breakdown, such as rheumatoid arthritis (RA) and osteoarthritis (OA) two main forms of arthritis.
biological activity	ARP-100 is a potent and selective inhibitor of matrix metalloproteinase MMP-2 (IC50=12 nM). ARP-100 interacts with MMP-2 of the S1 'pocket and shows anti-invasion properties in an invasion model of matrigel in vitro. The inhibitory activity of ARP-100 against MMP-1 (>50 μm),MMP-3 (4.5 μm),MMP-7 (>50 μm) and MMP-9 (0.2 μm) was small.

Last Update：2024-04-10 22:41:03

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CAS: 704888-90-4
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Email: 3008007409@qq.com
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QQ: 3008007409

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