N-tert-Butyl-5-bromothiophene-2-sulfonamide

N-tert-Butyl-5-bromothiophene-2-sulfonamide - Names and Identifiers

Name	5-Bromo-N-tert-butyl-2-thiophenesulfonamide
Synonyms	N-tert-Butyl-5-bromothiophene sulfonamide 5-bromo-N-tert-butylthiophene-2-sulfonamide N-tert-Butyl-5-bromothiophene-2-sulfonamide N-tert-Butyl 5-BroMo-2-thiophenesulfonaMide N-tert-Butyl 5-Bromo-2-thiophenesulfonamide 5-broMo-N-tert-butylthiophene-2-sulfonaMide 5-Bromo-N-tert-butyl-2-thiophenesulfonamide 5-Bromo-N-(tert-butyl)thiophene-2-sulphonamide
CAS	286932-39-6
EINECS	214-402-0
InChI	InChI=1/C8H12BrNO2S2/c1-8(2,3)10-14(11,12)7-5-4-6(9)13-7/h4-5,10H,1-3H3

N-tert-Butyl-5-bromothiophene-2-sulfonamide - Physico-chemical Properties

Molecular Formula	C8H12BrNO2S2
Molar Mass	298.22
Density	1.527
Melting Point	62℃
Boling Point	366.1±52.0 °C(Predicted)
Flash Point	175.2°C
Vapor Presure	1.5E-05mmHg at 25°C
Appearance	Yellow crystal
pKa	11.53±0.50(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.565
MDL	MFCD01569259

N-tert-Butyl-5-bromothiophene-2-sulfonamide - Risk and Safety

Hazard Symbols

Xi - Irritant

N-tert-Butyl-5-bromothiophene-2-sulfonamide - Introduction

Also known as a crystal, it is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless crystal or white solid.
-Melting point: Its melting point is about 130-131 degrees Celsius.
-Solubility: In common organic solvents such as dimethylformamide (DMF) or dichloromethane (DCM), it has good solubility.

Use:
As an important organic synthesis intermediate, it has many applications in organic synthesis:
-It can be used to synthesize compounds with medicinal activity, such as anti-cancer drugs.
-As a catalyst and ligand, participate in different types of catalytic reactions, such as Suzuki-Miyaura cross-coupling reactions in organic synthesis.
-can be used to prepare other compounds containing thiophene and sulfonamide functional groups.

Method:
It can be prepared by the following steps:
1. First, 2-thienesulfinamide (2-Thiophenesulfinamide) is reacted with bromine under appropriate conditions to obtain 5-bromothiophene-2-sulfamide (pyridine).
2. Then, 5-bromothiophene-sulfamide is reacted with tert-butanol under acidic conditions to generate pyridine.

Safety Information:
Pay attention to the following safety precautions when handling the solder:
-This is a chemical that must be stored properly and avoid contact with skin and eyes.
-Personal protective equipment such as gloves and goggles should be used during use.
-It should be used in a well-ventilated place and avoid inhaling its vapors.
-If you accidentally inhale or come into contact with the compound, wash the affected area immediately and seek medical help when needed.

Last Update：2024-04-09 21:01:54